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Anesthesia: Malignant Hyperthermia Response

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Topic Overview

Malignant hyperthermia is a rare, inherited (genetic) disorder that is potentially fatal. It can be triggered by exposure to certain anesthetics or muscle relaxants.

The disorder is caused by a reaction in muscle that leads to activation of the muscles. This causes a very high body temperature and the breakdown of muscle tissue.

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Important It is possible that the main title of the report CARASIL is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

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Anesthesia specialists can usually detect malignant hyperthermia early and treat it immediately. If it happens, malignant hyperthermia typically occurs during anesthesia or shortly after the surgery.

You may have an increased chance of getting malignant hyperthermia if:

  • You or a family member may have had malignant hyperthermia before.
  • You have a disease that affects the muscles.

You can have a test to help find out if you have an increased chance of getting this disorder.

If a person who is at possible risk of malignant hyperthermia needs anesthesia, the condition can be safely and completely avoided by choosing anesthetics that do not trigger malignant hyperthermia.

You can get more information about malignant hyperthermia from the Malignant Hyperthermia Association of the United States (MHAUS). Go to the website at


WebMD Medical Reference from Healthwise

Last Updated: September 09, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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