How It Works
Antiplatelets work in various ways to prevent blood clots.
Why It Is Used
This medicine may be used instead of aspirin, or along with aspirin, in people who have peripheral arterial disease. It might be used after a person has had a procedure such as bypass
How Well It Works
This medicine can prevent the formation of blood clots in people
peripheral arterial disease (PAD). Antiplatelet medicines may help lower the risk of
heart attack and
stroke in people who have PAD.2
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
- Usually the benefits of the medicine are more important than any minor side effects.
- Side effects may go away after you take the medicine for a while.
- If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.
Call 911 or other emergency services right away if you have:
- Trouble breathing.
- Swelling of your face, lips, tongue, or throat.
- Coughing up blood, vomiting blood, or passing black, tarry, or bloody stools. (These are signs of bleeding inside your body.)
Call your doctor right away if you have any unusual bleeding, such as:
- Blood spots under your skin.
- A nosebleed that you cannot stop.
- Bleeding gums when you brush your teeth.
Other side effects of this medicine include:
- Stomach pain or discomfort.
See Drug Reference for a full list of side effects. (Drug Reference
is not available in all systems.)
What To Think About
Risk of bleeding
Antiplatelet medicine increases the risk of bleeding. This risk of bleeding is higher in some people. Your doctor will balance the benefits and risks of an antiplatelet based on your health.
have a high risk of bleeding from taking an antiplatelet, your doctor may
suggest you take a
proton pump inhibitor or a histamine H2 acid reducer. This medicine may help prevent
bleeding in your stomach. If you are taking both aspirin and
an antiplatelet, talk with your doctor about how you can lower your risk of
Testing for clopidogrel
A genetic test might be used if your doctor thinks that your body is not using clopidogrel properly. This test checks to see if you have genes that let your body use clopidogrel. But experts aren't yet sure whether genetic changes keep clopidogrel from preventing a heart attack or stroke.
This genetic test alone is not enough to tell whether the medicine will help you. You also may have a test that shows how your body's platelets are working to clot blood. Having a platelet test after you take an antiplatelet can show if the medicine is working.
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Advice for women
If you are pregnant, breast-feeding, or trying to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments. And call your doctor if you are having problems. It’s also a good idea to know your test results and keep a list of the medicines you take.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
Rooke TW, et al. (2011). 2011 ACCF/AHA Focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline): A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology, 58(19): 2020–2045.
Hirsch AT, et al. (2006). ACC/AHA 2005 practice
guidelines for the management of patients with peripheral arterial disease
(lower extremity, renal, mesenteric, and abdominal aortic): A collaborative
report from the American Association for Vascular Surgery/Society for Vascular
Surgery, Society for Cardiovascular Angiography and Interventions, Society for
Vascular Medicine and Biology, Society of Interventional Radiology, and the
ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop
Guidelines for the Management of Patients With Peripheral Arterial Disease):
Endorsed by the American Association of Cardiovascular and Pulmonary
Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular
Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease
Foundation. Circulation, 113(11): e463–e654.
Primary Medical Reviewer
||Rakesh K. Pai, MD, FACC - Cardiology, Electrophysiology
Specialist Medical Reviewer
||David A. Szalay, MD - Vascular Surgery
||October 18, 2011