The abnormal breakdown and replacement of bone tissue in Paget's disease
may lead to bone deformities such as bowed legs as shown in the picture.
Paget's disease may also lead to an enlarged skull or hips or a curved
backbone. Deformities are more common in long bones, such as the thighbone
A bone affected by Paget's disease can cause
complications. For example, if the upper leg bows, it may change how the bones
that form the hip joint and knee joint fit together and move, leading to
osteoarthritis. Osteoarthritis, in turn, can cause pain and stiffness in the
joints and difficulty with walking and other daily activities.
Primary Medical Reviewer
Anne C. Poinier, MD - Internal Medicine
Specialist Medical Reviewer
Jennifer Hone, MD, MD - Endocrinology, Diabetes and Metabolism
September 1, 2011
WebMD Medical Reference from Healthwise
September 01, 2011
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