Skip to content

Information and Resources

Font Size
A
A
A

Cold Agglutinins

A cold agglutinins blood test is done to check for conditions that cause the body to make certain types of antibodies called cold agglutinins. Cold agglutinins are normally made by the immune system camera.gif in response to infection. They cause red blood cells to clump together (agglutinate) at low temperatures.

Healthy people generally have low levels of cold agglutinins in their blood. But lymphoma or some infections, such as mycoplasma pneumonia, can cause the level of cold agglutinins to rise.

Higher-than-normal levels of cold agglutinins generally do not cause serious problems. Sometimes, high levels of cold agglutinins can cause blood to clump in blood vessels under the skin when the skin is exposed to the cold. This causes pale skin and numbness in the hands and feet. The symptoms go away when the skin warms up. In some cases, the clumped blood cells can stop the flow of blood to the tips of the fingers, toes, ears, or nose. This is like frostbite and can cause tissue damage. In rare cases, it can cause gangrene.

Sometimes high levels of cold agglutinins can destroy red blood cells throughout the body. This condition is called autoimmune hemolytic anemia.

Why It Is Done

The cold agglutinins test may be done to:

  • See whether high cold agglutinin levels are causing autoimmune hemolytic anemia.
  • Find pneumonia caused by mycoplasma. Over half of people with pneumonia caused by mycoplasma develop an increase in cold agglutinin levels in their blood within a week of being infected. Newer tests for mycoplasma pneumonia have replaced the cold agglutinins blood test.

How To Prepare

You do not need to do anything before you have this test.

How It Is Done

The doctor drawing blood will:

  • Wrap an elastic band around your upper arm to stop the flow of blood. This makes the veins below the band larger so it is easier to put a needle into the vein.
  • Clean the needle site with alcohol.
  • Put the needle into the vein. If the needle is not placed correctly or if the vein collapses, more than one needle stick may be needed.
  • Hook a tube to the needle to fill it with blood.
  • Remove the band from your arm when enough blood is collected.
  • Put a gauze pad or cotton ball over the needle site as the needle is removed.
  • Put pressure on the site and then put on a bandage.
1 | 2 | 3

WebMD Medical Reference from Healthwise

Last Updated: March 12, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

Hot Topics

WebMD Video: Now Playing

Click here to wach video: Dirty Truth About Hand Washing

Which sex is the worst about washing up? Why is it so important? We’ve got the dirty truth on how and when to wash your hands.

Click here to watch video: Dirty Truth About Hand Washing

Popular Slideshows & Tools on WebMD

sore foot
3 warning signs.
acupuncture needle on shoulder
10 tips to look and feel good.
mature woman holding fan in face
Symptoms and treatments.
disciplining a boy
Types, symptoms, causes.
psoriasis
What it looks like.
checking blood sugar
Symptoms and treatment.
man behind computer screen
10 possible causes.
Woman with itchy watery eyes
Common triggers.
man screaming
Making sense of symptoms.
human liver
What puts you at risk?
caregiver with parent
10 tips for daily life.
two male hands
Understanding RA.

Pollen counts, treatment tips, and more.

It's nothing to sneeze at.

Loading ...

Sending your email...

This feature is temporarily unavailable. Please try again later.

Thanks!

Now check your email account on your mobile phone to download your new app.

Women's Health Newsletter

Find out what women really need.