Skip to content

Information and Resources

Font Size
A
A
A

Cold Agglutinins

What Affects the Test

You may not be able to have this test or the results may not be helpful if you are taking antibiotics, especially penicillin and cephalosporins.

What To Think About

  • More than half of people infected with pneumonia caused by mycoplasma develop high levels of cold agglutinins. Newer tests for mycoplasma pneumonia have replaced the cold agglutinins blood test.
  • If clumped red blood cells (called a Rouleaux formation) are seen on a complete blood count (CBC) test, your doctor may order a cold agglutinins test to see whether high cold agglutinin levels are present.
  • A blood type test is done before a blood transfusion or organ transplant to make sure that the donor's and recipient's blood types match. Blood that has high levels of cold agglutinins may be hard to type. To learn more about blood typing, see the topic Blood Type Test.
  • If a person has high levels of cold agglutinins and has symptoms brought on by cold temperatures, it is important for this person to be kept warm. High levels of cold agglutinins in this case could lead to frostbite, anemia, or Raynaud's phenomenon. Medicines to help lower high levels of cold agglutinins may be given when severe symptoms are brought on by cold exposure.
  • Older adults may have high titers of cold agglutinins that last for years.
  • Cold agglutinins in the blood can cause problems with automated machines that measure blood count.

Citations

  1. Fischbach FT, Dunning MB III, eds. (2009). Manual of Laboratory and Diagnostic Tests, 8th ed. Philadelphia: Lippincott Williams and Wilkins.

Other Works Consulted

  • Chernecky CC, Berger BJ (2008). Laboratory Tests and Diagnostic Procedures, 5th ed. St. Louis: Saunders.

  • Fischbach FT, Dunning MB III, eds. (2009). Manual of Laboratory and Diagnostic Tests, 8th ed. Philadelphia: Lippincott Williams and Wilkins.

  • Pagana KD, Pagana TJ (2010). Mosby’s Manual of Diagnostic and Laboratory Tests, 4th ed. St. Louis: Mosby Elsevier.

By Healthwise Staff
Primary Medical Reviewer E. Gregory Thompson, MD - Internal Medicine
Specialist Medical Reviewer W. David Colby IV, MSc, MD, FRCPC - Infectious Disease
Current as of March 12, 2014
1 | 2 | 3

WebMD Medical Reference from Healthwise

Last Updated: March 12, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

Hot Topics

WebMD Video: Now Playing

Click here to wach video: Dirty Truth About Hand Washing

Which sex is the worst about washing up? Why is it so important? We’ve got the dirty truth on how and when to wash your hands.

Click here to watch video: Dirty Truth About Hand Washing

Popular Slideshows & Tools on WebMD

feet
Solutions for 19 types.
MS Overview
Recognizing symptoms.
pregnancy test and calendar
Helping you get pregnant.
build a better butt
How to build a better butt.
lone star tick
How to identify that bite.
woman standing behind curtains
How it affects you.
brain scan with soda
Tips to avoid complications.
row of colored highlighter pens
Tips for living better.
psoriasis
How to keep flares at bay.
woman dreaming
What Do Your Dreams Say About You?
spinal compression fracture
Treatment options.

Pollen counts, treatment tips, and more.

It's nothing to sneeze at.

Loading ...

Sending your email...

This feature is temporarily unavailable. Please try again later.

Thanks!

Now check your email account on your mobile phone to download your new app.

Women's Health Newsletter

Find out what women really need.