To understand the use and outcomes of on-demand and regularly
scheduled clotting factor replacement, a European study compared treatment
outcomes during 1997 for two groups of people with severe hemophilia. All 155
participants in the study were born between 1970 and 1981. The group of 106
treated in France had primarily received on-demand treatment, while the group
of 49 treated in the Netherlands had primarily received regularly scheduled
The study measured the frequency of joint bleeding episodes and the
amount of clotting factor that was received by participants during a single
year. The study also measured the participants' health-related quality of life,
including mental and general health, role limitations, and pain.
Graph 1 shows the general health of
participants during 1997 compared with the general population. A higher score
reflects better general health, while a lower score reflects poorer general
health. Participants receiving on-demand treatment reported poorer general
health, while participants receiving regularly scheduled treatment reported
better general health.
Graph 2 shows the average number of joint
bleeding episodes participants had during 1997.
Graph 3 shows the average amount of clotting
factor replacement in international units (IU) that participants received
Fischer K, et al. (2002). Prophylactic versus on-demand
treatment strategies for severe haemophilia: A comparison of costs and
long-term outcome. Haemophilia, 8(6): 745-752.
Primary Medical Reviewer
Anne C. Poinier, MD - Internal Medicine
Specialist Medical Reviewer
Brian Leber, MDCM, FRCPC - Hematology
August 20, 2007
WebMD Medical Reference from Healthwise
August 20, 2007
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