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Cushing's Syndrome: Corticotropin-Releasing Hormone

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The corticotropin-releasing hormone (CRH) stimulation test helps determine whether a pituitary tumor may be causing Cushing's syndrome. It is sometimes done with an inferior petrosal sinus sampling (IPSS) test.

In these tests, a small tube (catheter) is used to collect samples from blood vessels coming from the pituitary gland near the brain and also from a vein in your arm. You will get an injection of CRH, and samples of your blood near your pituitary gland and from your arm are taken.

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If these blood samples show high levels of adrenocorticotropic hormone (ACTH) and cortisol, it usually indicates that the pituitary gland has a tumor.

If blood levels of ACTH and cortisol do not rise, your doctor may then look for an adrenal tumor or a cancerous tumor elsewhere in your body.

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WebMD Medical Reference from Healthwise

Last Updated: January 10, 2012
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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