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The First and Only FDA-Approved Nonsurgical Treatment Option for Dupuytren's Contracture Is Within Reach

This content is from our sponsor. The sponsor has sole editorial control.

Is Dupuytren's contracture impacting you?

Find a hand specialist in your area who is experienced in administering XIAFLEX®.

How XIAFLEX® Works

XIAFLEX® is the first and only FDA-approved nonsurgical treatment option for adults with Dupuytren's contracture when a "cord" can be felt. Your doctor may call this a "palpable cord." That means it is raised above the palm and can be felt easily during an examination.

A cord forms containing excess collagen. Over time, the cord thickens and shortens causing your finger(s) to bend toward the palm.

Degress of Contracture

XIAFLEX® is a medicine that is injected directly into a Dupuytren's cord. This medicine helps break down collagen in the cord that then helps the finger to straighten.

Prescription XIAFLEX® is injected into the Dupuytren's cord by a hand specialist who is experienced in administering XIAFLEX®. If needed, 1 day later, the doctor will extend the treated finger to help break the cord. No incisions are required to administer XIAFLEX®. Up to 3 injections may be given into the cord at
30-day intervals.

Until XIAFLEX®, adults with Dupuytren's contracture had few options for effective treatment outside of surgery.

The information on this Web site should not take the place of talking with your doctor or healthcare provider. If you have any questions, talk to your doctor or pharmacist.

About XIAFLEX®

XIAFLEX® is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. Over time, the thickening and shortening of this cord in the hand can cause one or more fingers to bend toward the palm, so that the finger(s) cannot be straightened. XIAFLEX helps to break down the cord that is causing the finger to be bent. XIAFLEX should be injected into the cord by a healthcare provider who is experienced in injection procedures of the hand and treating people with Dupuytren's contracture.

Important Safety Information

XIAFLEX can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit.
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, or increased pain in your treated finger or hand after your injection or after your follow-up visit.
  • Allergic Reactions. Allergic reactions can happen in people who have received an injection of XIAFLEX because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX: hives; swollen face; breathing trouble; or chest pain.

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Be sure to tell them if you use blood thinners such as aspirin, clopidogrel (Plavix®), prasugrel hydrochloride (Effient®), or warfarin sodium (Coumadin®).

Common side effects with XIAFLEX include: swelling of the injection site or the hand; bleeding or bruising at the injection site; pain or tenderness of the injection site or the hand; swelling of the lymph nodes (glands) in the elbow or underarm; itching; breaks in the skin; redness or warmth of the skin; and pain in the underarm.

Please see Full Prescribing Information and Medication Guide.

INDICATION AND IMPORTANT SAFETY INFORMATION

About XIAFLEX®

XIAFLEX® is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. Over time, the thickening and shortening of this cord in the hand can cause one or more fingers to bend toward the palm, so that the finger(s) cannot be straightened. XIAFLEX helps to break down the cord that is causing the finger to be bent. XIAFLEX should be injected into the cord by a healthcare provider who is experienced in injection procedures of the hand and treating people with Dupuytren's contracture.

Important Safety Information

XIAFLEX can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit.
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, or increased pain in your treated finger or hand after your injection or after your follow-up visit.
  • Allergic Reactions. Allergic reactions can happen in people who have received an injection of XIAFLEX because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX: hives; swollen face; breathing trouble; or chest pain.

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Be sure to tell them if you use blood thinners such as aspirin, clopidogrel (Plavix®), prasugrel hydrochloride (Effient®), or warfarin sodium (Coumadin®).

Common side effects with XIAFLEX include: swelling of the injection site or the hand; bleeding or bruising at the injection site; pain or tenderness of the injection site or the hand; swelling of the lymph nodes (glands) in the elbow or underarm; itching; breaks in the skin; redness or warmth of the skin; and pain in the underarm.

Please see Full Prescribing Information and Medication Guide.

Is Dupuytren's Contracture Impacting You?

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XIAFLEX® May Be the Right Choice

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Find an experienced hand specialist in your area.