Skip to content
This content is from our sponsor. The sponsor has sole editorial control.

Receiving Treatment: A Step-By-Step Guide

This content is from our sponsor. The sponsor has sole editorial control.

Find a hand specialist in your area who is experienced
in administering XIAFLEX®.

How XIAFLEX® Is Administered

XIAFLEX® is a medicine that is injected directly into the Dupuytren's cord. You can get treated by a hand specialist in your area who is experienced in administering XIAFLEX®.

XIAFLEX® can cause serious side effects such as tendon rupture, ligament damage, nerve injury or other serious injury of the hand, or allergic reaction.

Call your doctor right away if you have trouble bending your injected finger after the swelling goes down, pain, tingling, numbness, or problems using your treated hand or if you get hives, swollen face, breathing trouble, or chest pain.

It's important to tell your doctor about a prior allergic reaction to XIAFLEX®, or if you have a bleeding problem or use a blood thinner.

Common side effects include hand swelling, bruising, injection site reaction or bleeding, and pain.

Please read the XIAFLEX® Medication Guide before you receive XIAFLEX® and each time you get an injection.

1) Day 1 — Injecting XIAFLEX®

  • First, your doctor will clean the area
  • Next, your doctor will inject XIAFLEX® into the cord that is causing your finger to be bent
  • Once the injection is over, your doctor will provide a bandage to cover your hand

If you have more than one cord and your hand specialist thinks it is appropriate, the next cord that you have may be treated with XIAFLEX® at a later time.

Tip: Limit moving and using the treated finger after the injection. Keep the injected hand elevated until bedtime. Your finger may straighten on its own before you see the doctor, but do not try to push it into a straighter position.

2) Next day follow-up with your hand specialist

  • You will return to your doctor for a follow-up visit about 24 hours after your XIAFLEX® injection(s). If the cord is still intact, your doctor will perform a follow-up procedure to unbend your finger and try to "break" the cord in order to straighten the finger. Many patients feel or hear a popping or cracking sound.
    Tip: At your follow-up visit, your doctor will give you a splint to wear at night to help keep your finger straight. You may also be shown finger exercises to do at home.
  • Follow your doctor's instructions about when you can start doing your normal activities with the injected hand

3) 30-day follow-up with your hand specialist*

  • After about 30 days have passed, you should see your doctor for a progress check
  • Because individual results may vary, your doctor may suggest repeating the XIAFLEX® treatment cycle (steps 1, 2, and 3) up to 3 times for each Dupuytren's cord at 30-day intervals*

*In clinical studies, 44% to 64% of patients receiving XIAFLEX® (versus 5% to 7% of patients receiving placebo) had a straight or near straight finger after up to 3 XIAFLEX® injections (most patients required 1 or 2 injections).

Find a hand specialist in your area who is experienced in administering XIAFLEX®.

What Should I Tell My Doctor Before Starting Treatment with XIAFLEX®?

XIAFLEX® may not be right for you. Before receiving XIAFLEX®, tell your healthcare provider if you:

  • have had an allergic reaction to a previous XIAFLEX® injection
  • have a bleeding problem
  • have any other medical conditions
  • are pregnant or plan to become pregnant. It is not known if XIAFLEX® will harm your unborn baby
  • are breastfeeding. It is not known if XIAFLEX® passes into your breast-milk. Talk to your healthcare provider about the best way to feed your baby if you receive XIAFLEX®

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you use:

  • a blood thinner medicine such as aspirin, clopidogrel (Plavix®), prasugrel hydrochloride (Effient®), or warfarin sodium (Coumadin®). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner

The information on this Web site should not take the place of talking with your doctor or healthcare provider. If you have any questions, talk to your doctor or pharmacist.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is XIAFLEX?

XIAFLEX is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. It is not known if XIAFLEX is safe and effective in children under the age of 18.

IMPORTANT SAFETY INFORMATION

Do not receive XIAFLEX if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.

XIAFLEX can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, or increased pain in your treated finger or hand after your injection or after your follow-up visit
  • Allergic reactions. Severe allergic reactions can happen in people who receive XIAFLEX because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:
    • hives
    • swollen face
    • breathing trouble
    • chest pain
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX for the treatment of Dupuytren's contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is XIAFLEX?

XIAFLEX is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. It is not known if XIAFLEX is safe and effective in children under the age of 18.

IMPORTANT SAFETY INFORMATION

Do not receive XIAFLEX if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.

XIAFLEX can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, or increased pain in your treated finger or hand after your injection or after your follow-up visit
  • Allergic reactions. Severe allergic reactions can happen in people who receive XIAFLEX because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:
    • hives
    • swollen face
    • breathing trouble
    • chest pain
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX for the treatment of Dupuytren's contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist.

Please see the accompanying full Prescribing Information and Medication Guide.

Do You Have Dupuytren's
Contracture?

From Our Sponsor

Learn about a nonsurgical treatment.

Does Dupuytren's Contracture Strike a Cord with You?

From Our Sponsor

Learn about a nonsurgical treatment.

XIAFLEX® May Be the Right Choice

From Our Sponsor

Find an experienced hand specialist in your area.