How XIAFLEX® Is Administered
XIAFLEX® is a medicine that is injected directly into the Dupuytren's cord. You can get treated by a hand specialist in your area who is experienced in administering XIAFLEX®.
XIAFLEX® can cause serious side effects such as tendon rupture, ligament damage, nerve injury or other serious injury of the hand, or allergic reaction.
Call your doctor right away if you have trouble bending your injected
finger after the swelling goes down, pain, tingling, numbness, or problems
using your treated hand or if you get hives, swollen face, breathing trouble,
or chest pain.
It's important to tell your doctor about a prior allergic reaction to
XIAFLEX®, or if you have a bleeding problem or use a blood thinner.
Common side effects include hand swelling, bruising, injection site
reaction or bleeding, and pain.
Please read the XIAFLEX®
Medication Guide before you receive XIAFLEX® and each time you get an injection.
1) Day 1 — Injecting XIAFLEX®
- First, your doctor will clean the area
- Next, your doctor will inject XIAFLEX® into the cord that is causing your finger to be bent
- Once the injection is over, your doctor will provide a bandage to
cover your hand
If you have more than one cord and your hand
specialist thinks it is appropriate, the next cord that you have may be
treated with XIAFLEX® at a later time.
Tip: Limit moving and using the treated finger after the
injection. Keep the injected hand elevated until bedtime. Your finger may
straighten on its own before you see the doctor, but do not try to push it
into a straighter position.
2) Next day follow-up with your hand specialist
3) 30-day follow-up with your hand specialist*
- After about 30 days have passed, you should see your doctor for a
- Because individual results may vary, your doctor may suggest
repeating the XIAFLEX® treatment cycle (steps 1, 2, and 3)
up to 3 times for each Dupuytren's cord at 30-day intervals*
*In clinical studies, 44% to 64% of patients receiving
XIAFLEX® (versus 5% to 7% of patients receiving placebo) had a straight or near straight finger after
up to 3 XIAFLEX® injections (most patients required 1 or 2 injections).
What Should I Tell My Doctor Before Starting Treatment with XIAFLEX®?
XIAFLEX® may not be right for you. Before receiving
XIAFLEX®, tell your healthcare provider if you:
- have had an allergic reaction to a previous XIAFLEX®
- have a bleeding problem
- have any other medical conditions
- are pregnant or plan to become pregnant. It is not known if
XIAFLEX® will harm your unborn baby
- are breastfeeding. It is not known if XIAFLEX® passes
into your breast-milk. Talk to your healthcare provider about the best way
to feed your baby if you receive XIAFLEX®
Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you use:
- a blood thinner medicine such as aspirin, clopidogrel
(Plavix®), prasugrel hydrochloride (Effient®),
or warfarin sodium (Coumadin®). If you are told to stop taking
a blood thinner before your XIAFLEX® injection, your healthcare
provider should tell you when to restart the blood thinner