Glomerulosclerosis refers to scarring or hardening of the glomeruli -- blood vessels located in the kidneys. The glomeruli filter the blood as it passes through the kidneys. They remove waste fluids that then leave the body as urine.
Damaged glomeruli can't perform their job adequately. As a result, large amounts of protein from the blood leak into the urine rather than remaining in the bloodstream. This leads to a condition called proteinuria.
The key to prevention or delay of severe kidney disease is early detection and aggressive intervention -- while there's still time to slow down the progression to kidney failure. Medical care with early intervention can change the course of chronic kidney disease and help prevent the need for dialysis or a kidney transplant.
Diabetes and high blood pressure account for two thirds of all cases of chronic kidney disease. By aggressively managing diabetes and high blood pressure with diet, exercise,...
Glomerulosclerosis can affect children and adults. Men are slightly more likely to develop it. African-Americans are at higher risk than whites.
Causes of Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a kidney disease that can lead to glomerulosclerosis. In FSGS, the scarring occurs only in some of the glomeruli. And only part of the individual glomeruli is damaged.
Untreated, it can lead to kidney failure. In some cases, kidney failure can occur despite treatment.
FSGS most frequently occurs without a cause. In such cases it is called idiopathic or primary FSGS. Sometimes, though, FSGS does have a known cause, and these can include: