Glomerulosclerosis refers to scarring or hardening of the glomeruli -- blood vessels located in the kidneys. The glomeruli filter the blood as it passes through the kidneys. They remove waste fluids that then leave the body as urine.
Damaged glomeruli can't perform their job adequately. As a result, large amounts of protein from the blood leak into the urine rather than remaining in the bloodstream. This leads to a condition called proteinuria.
"I'll give you one of mine," Ann Lopez said to her husband the
moment the couple learned he would need a kidney transplant. He thought she was
joking. But George Lopez, star of ABC's The George Lopez Show, is the
comic, not his wife.
And so, just before sunrise on a Tuesday in April of 2005, the Lopezes
arrived at Cedars-Sinai Medical Center in Los Angeles, where they were prepped
for surgery in neighboring rooms. Right before Ann was wheeled to the operating
room --- her surgery began first...
Glomerulosclerosis can affect children and adults. Men are slightly more likely to develop it. African-Americans are at higher risk than whites.
Causes of Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a kidney disease that can lead to glomerulosclerosis. In FSGS, the scarring occurs only in some of the glomeruli. And only part of the individual glomeruli is damaged.
Untreated, it can lead to kidney failure. In some cases, kidney failure can occur despite treatment.
FSGS most frequently occurs without a cause. In such cases it is called idiopathic or primary FSGS. Sometimes, though, FSGS does have a known cause, and these can include: