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Health problems associated with adult obesity

Adults withobesityare more likely to have certain health problems than adults who are not obese. These problems include the following.

Heart disease and cardiovascular problems

People who are obese have an increased risk of:¹

Heart disease, includingcoronary artery disease,heart attack,heart failure,angina, and anabnormal heartbeat.
High blood pressure. High blood pressure in obese men may in turn increase the risk of kidney cancer.²
High levels of cholesterolandtriglyceridesin the blood, as well as lower levels of "good"HDL cholesterol.
Stroke.

Diabetes

People who are obese are more likely to developinsulin resistance, which can lead totype 2 diabetes.¹One study has noted that men and women who have abody mass index (BMI)over 35 are approximately 20 times more likely to develop diabetes over a 10-year period than people with a normal weight (a BMI of 18.5 to 24.9).³

The risk of type 2 diabetes increases as BMI increases. People who have a large percentage of body fat in the abdominal area-greater than40inin men and greater than35inin women-are at increased risk for type 2 diabetes, even if their BMIs are within the normal range. Weight gain of more than17.5lbafter age 21 in men or22lbafter age 18 in women further increases the risk for type 2 diabetes.⁴

Cancer

People who are obese may be at greater risk for different types of cancer, including:^1,⁵

Digestive problems

People who are obese may have more digestive problems.⁶

Women who are obese have twice the risk of developinggallstonesas women of normal weight, and women who are extremely obese (a BMI over 45) have 7 times the risk.
A few studies report that people who are obese and who developpancreatitishave worse outcomes than people of normal weight.
Obesity is associated with liver problems such as an enlarged liver (hepatomegaly), a fatty liver (steatosis), orcirrhosis.
Symptoms ofgastroesophageal reflux disease (GERD)are more common in people who are obese than in people of normal weight.

Breathing problems

People who are obese may have difficulty breathing.

They are more likely to havesleep apnea. Although about 1% to 4% of all people have breathing problems while sleeping, about 24% of overweight men and 9% of overweight women do.⁷
Obesity is associated with a higher prevalence ofasthma.¹
People who are obese tend to take smaller or shallower breaths (pickwickian syndrome). These small, gasping breaths may not get as much oxygen into the blood as needed, leaving them always tired. Pickwickian syndrome can eventually lead to heart problems.

Arthritis

People who are obese have a greater risk of developingarthritis.

Extra weight puts more stress on the joints than normal, especially in the legs and lower back.
For every2lbincrease in weight, the risk of developing arthritis increases 9% to 13%.¹

Sex hormone problems

Obesity is associated with:

Problems with becoming pregnant (infertility).⁶
Irregular menstrual periods.⁶
Increased risk of death for mother and baby.¹
Increased risk of birth defects, especiallyneural tube defects.¹

Other Problems

Kidney disease.⁸

Citations

U.S. Department of Health and Human Services (2001).The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity. Washington, DC: U.S. Department of Health and Human Services. Available online: http://www.surgeongeneral.gov/topics/obesity.

Chow WH, et al. (2000). Obesity, hypertension, and the risk of kidney cancer in men.New England Journal of Medicine, 343(18): 1305-1311.

Field AE, et al. (2001). Impact of overweight on the risk of developing common chronic diseases during a 10-year period.Archives of Internal Medicine, 161(13): 1581-1586.

Capes S, Anand S (2001). What is type 2 diabetes? In HC Gerstein, RB Haynes, eds.,Evidence-Based Diabetes Care, pp. 151-163. Hamilton, ON: BC Decker.

Hampel H, et al. (2005). Meta-analysis: Obesity and the risk for gastroesophageal reflux disease and its complications.Annals of Internal Medicine, 143(3): 199-211.

American Gastroenterological Association (2002). AGA technical review on obesity.Gastroenterology, 123(3): 882-932. [Erratum inGastroenterology, 123(5): 1752.

Allison DB, Saunders SE (2000). Obesity in North America: An overview.Medical Clinics of North America, 84(2): 305-332.

Ejerblad E, et al. (2006). Obesity and risk for chronic renal failure.Journal of the American Society of Nephrology, 17(6): 1695-1702.

Author	Jeannette Curtis
Editor	Kathleen M. Ariss, MS
Associate Editor	Pat Truman, MATC
Primary Medical Reviewer	Caroline S. Rhoads, MD - Internal Medicine
Specialist Medical Reviewer	Matthew I. Kim, MD - Endocrinology & Metabolism
Last Updated	April 16, 2009

WebMD Medical Reference from Healthwise

Last Updated: April 16, 2009

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