There are no specific medicines used to
Over-the-counter medicines may be used to help treat
the symptoms of mono.
Over-the-counter pain relievers, including
acetaminophen (such as Tylenol) and ibuprofen (such as Advil), may be used to
relieve headaches and a sore throat. Do not give aspirin
to anyone under the age of 20, because its use has been linked with
Reye syndrome, a serious illness.
In severe cases,
corticosteroids may be used to reduce swelling of the
throat, tonsils, or
Taking antibiotics such as amoxicillin or ampicillin may
cause a rash in many people who have mono.1 A rash
caused by antibiotics can often be a first sign that the person has mono. The
rash is not an allergic reaction.2
Antiviral drugs do not improve
the symptoms of mono or shorten the length of the illness.4
What to think about
Nonprescription medicines are commonly used to relieve
symptoms, but they do not shorten the duration of the illness.