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Medicines and Other Substances That Can Cause Symptoms of Depression

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Many medicines can cause changes in how we feel. Some can cause symptoms of depression. These include:

  • Blood pressure medicines, such as clonidine (Catapres).
  • Barbiturates. Some examples are pentobarbital (Nembutal), phenobarbital, and secobarbital (Seconal).
  • Benzodiazepines. Some examples are alprazolam (Xanax), diazepam (Valium), and lorazepam (Ativan).
  • Calcium channel blockers, such as verapamil (Calan).
  • Corticosteroids, such as prednisone.
  • Hormonal medicines. Some examples are birth control pills and hormone therapy used to treat the symptoms of menopause.
  • Isotretinoin (Claravis). This is an acne medicine.
  • Medicines used to treat Parkinson's disease or other nervous system problems, such as restless legs syndrome.
  • Medicines used to treat seizures, such as phenytoin (Dilantin).
  • Pain medicines, such as codeine or morphine.

Symptoms of depression can also be caused by the use of or withdrawal from alcohol and illegal drugs. Cocaine, amphetamines (methamphetamines, crystal meth, or crack), heroin, and marijuana can all cause symptoms of depression.

Did You Know?

Under the Affordable Care Act, many health insurance plans will cover preventive mental health services, including screening tests for depression and alcohol misuse, at no cost to you. Learn more.

Health Insurance Center

If you think that your feelings of depression may be caused by a medicine:

  • Call the doctor who prescribed the medicine. Ask if you should stop taking it or take a different one.
  • If you are taking a nonprescription medicine, stop taking it. If you feel you need to keep taking it, call your doctor. There might be a different medicine you can take.
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WebMD Medical Reference from Healthwise

Last Updated: November 14, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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