In cases without complications, mumps is treated with bed rest and care at home.

Home treatment includes medicines you can buy without a prescription to relieve pain and reduce fever. Acetaminophen (for example, Tylenol) or nonsteroidal anti-inflammatory medicines (for example, Advil, Motrin, Aleve) are often used. Do not give aspirin to anyone younger than 20 because of its link to a rare but serious illness called Reye's syndrome.

Complications may require treatment in the hospital. Medicines to relieve pain associated with orchitis, meningitis, pancreatitis, and other complications may be given. Treatment with other medicines, such as interferon for severe orchitis, is experimental. Antibiotics are not given to treat mumps or other viral infections.