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General Information About Islet Cell Tumors (Endocrine Pancreas)

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Glucagonoma

  • Fasting serum glucagon test: A test in which a blood sample is checked to measure the amount of glucagon in the blood. The test is done after the patient has had nothing to eat or drink for at least 8 hours.

Other tumor types

  • VIPoma
    • Serum VIP (vasoactive intestinal peptide) test: A test in which a blood sample is checked to measure the amount of VIP.
    • Blood chemistry studies: A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease in the organ or tissue that makes it. In VIPoma, there is a lower than normal amount of potassium.
    • Stool analysis: A stool sample is checked for a higher than normal sodium (salt) and potassium levels.
  • Somatostatinoma
    • Fasting serum somatostatin test: A test in which a blood sample is checked to measure the amount of somatostatin in the blood. The test is done after the patient has had nothing to eat or drink for at least 8 hours.
    • Somatostatin receptor scintigraphy: A type of radionuclide scan that may be used to find small islet cell tumors. A small amount of radioactive octreotide (a hormone that attaches to tumors) is injected into a vein and travels through the blood. The radioactive octreotide attaches to the tumor and a special camera that detects radioactivity is used to show where the tumors are in the body. This procedure is also called octreotide scan and SRS.
  • PPoma
    • Fasting serum polypeptide test: A test in which a blood sample is checked to measure the amount of pancreatic polypeptide in the blood. The test is done after the patient has had nothing to eat or drink for at least 8 hours.
    • Somatostatin receptor scintigraphy: A type of radionuclide scan that may be used to find small islet cell tumors. A small amount of radioactive octreotide (a hormone that attaches to tumors) is injected into a vein and travels through the blood. The radioactive octreotide attaches to the tumor and a special camera that detects radioactivity is used to show where the tumors are in the body. This procedure is also called octreotide scan and SRS.
    • Atropine suppression test: A test used to help find out if the secretion of a polypeptide (protein) by the pancreas is normal or caused by a tumor. A drug called atropine, which can lessen secretions, is injected into a vein. After the injection, pancreatic polypeptide levels in the blood stay the same in patients with tumors, but drop in patients without tumors.
    • Immunohistochemistry study: A laboratory test in which a substance such as an antibody, dye, or radioisotope is added to a sample of cancer tissue to test for certain antigens.

Certain factors affect prognosis (chance of recovery) and treatment options.

Islet cell tumors can often be cured. The prognosis (chance of recovery) and treatment options depend on the following:

  • The type of cancer cell.
  • Where the tumor is found in the pancreas.
  • Whether the tumor has spread to more than one place in the pancreas or to other parts of the body.
  • Whether the patient has MEN1 syndrome.
  • The patient's age and general health.
  • Whether the cancer has just been diagnosed or has recurred (come back).
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WebMD Public Information from the National Cancer Institute

Last Updated: October 07, 2011
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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