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Nephrotic Syndrome

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Symptoms

Many people who have nephrotic syndrome do not have any noticeable physical symptoms. When symptoms are present, they can include:

  • Swelling in the tissues around the eyes (periorbital edema) or in the feet or ankles (peripheral edema). This is the most common early symptom of nephrotic syndrome in both children and adults.
  • Shortness of breath caused by fluid buildup in the lungs (pulmonary edema).
    • Adults older than 65 may be misdiagnosed with heart failure.
    • Children are often thought to have allergies.
  • Dry skin.
  • Swelling of the scrotum (scrotal edema), which may cause a cord in the testicles to twist (testicular torsion).

Signs of nephrotic syndrome in blood and urine tests can include:

Recommended Related to Kidney Disorders

Glomerulosclerosis

Glomerulosclerosis refers to scarring or hardening of the glomeruli -- blood vessels located in the kidneys. The glomeruli filter the blood as it passes through the kidneys. They remove waste fluids that then leave the body as urine. Damaged glomeruli can't perform their job adequately. As a result, large amounts of protein from the blood leak into the urine rather than remaining in the bloodstream. This leads to a condition called proteinuria. Glomerulosclerosis can affect children and adults...

Read the Glomerulosclerosis article > >

  • Protein in the urine (proteinuria).
  • Low protein (albumin) in the blood.
  • High cholesterol and triglyceride levels.
  • Low blood levels of iron and vitamin D.
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WebMD Medical Reference from Healthwise

Last Updated: May 17, 2011
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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