Skip to content

OCD Medicines Other Than SSRIs

Font Size

Topic Overview

Although selective serotonin reuptake inhibitors (SSRIs) are most often used to treat obsessive-compulsive disorder (OCD), there are other medicines that may be used or added to SSRI medicines for OCD.

Risperidone (Risperdal) is one such medicine that sometimes is added to SSRI treatment of OCD. Risperidone has been shown to reduce depression and anxiety symptoms in people with OCD whose symptoms have not responded to an SSRI alone.1 Risperidone is an antipsychotic drug that can cause some negative side effects, such as:

Recommended Related to Sex & Relationships

Standing by Her Man: Why?

Fashionably dressed and smoothly coiffed, New York first lady Silda Spitzer's expression seemed to convey a mixture of sadness and rage during the Monday press conference where her husband, New York Gov. Eliot Spitzer, publicly apologized over his alleged involvement in a prostitution ring. The news videos headlining the alleged infidelity of a powerful man brought up other similar images of late -- Bill and Hillary Clinton, former New Jersey Gov. James McGreevey and his wife, Dina, and Idaho Sen...

Read the Standing by Her Man: Why? article > >

  • Problems with thinking, reasoning, or remembering.
  • Fatigue or sleepiness.
  • Weight gain.
  • Abnormal cholesterol or blood sugar levels.
  • Movement disorders.

The makers of Risperdal (risperidone) have recently issued a warning that there may be an increased risk of stroke among older adults who take this medicine. Discuss this risk with your doctor before trying Risperdal (risperidone).

Another medicine that might be added to SSRI treatment of OCD is clonazepam. Clonazepam is considered both an anticonvulsant and a benzodiazepine medicine. It sometimes is used to treat anxiety disorders as well as Tourette's disorder (a tic disorder). Research is ongoing to find out how effective it is to add clonazepam to an SSRI to treat OCD.

If other mental health disorders (such as depression) are present along with OCD, it may be necessary to treat the disorders at the same time with additional medicines that may include:

  • Mood stabilizers (such as carbamazepine), sometimes used to treat depression.
  • Antianxiety medicines (such as alprazolam), sometimes used to treat anxiety disorders.
  • Atypical antipsychotic medicines (such as olanzapine), sometimes used to treat severe OCD if the person experiences a loss of reality, paranoia, and/or psychosis.

The U.S. Food and Drug Administration (FDA) has issued a warning on anticonvulsant and mood stabilizer medicines and the risk of suicide and suicidal thoughts. The FDA does not recommend that people stop using these medicines. Instead, people who take anticonvulsant or mood stabilizer medicine should be watched closely for warning signs of suicide. People who take anticonvulsant or mood stabilizer medicine and who are worried about this side effect should talk to a doctor.

See Drug Reference for more information about these medicines. (Drug Reference is not available on all systems.)

1

WebMD Medical Reference from Healthwise

Last Updated: November 14, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
Next Article:

OCD Medicines Other Than SSRIs Topics

Hot Topics

WebMD Video: Now Playing

Click here to wach video: Dirty Truth About Hand Washing

Which sex is the worst about washing up? Why is it so important? We’ve got the dirty truth on how and when to wash your hands.

Click here to watch video: Dirty Truth About Hand Washing

Popular Slideshows & Tools on WebMD

disciplining a boy
Types, symptoms, causes.
psoriasis
Does your kid have symptoms?
fruit drinks
Eat these to think better.
No gym workout
Moves to help control blood sugar.
acupuncture needle on shoulder
10 tips to look and feel good.
Close up of eye
12 reasons you're distracted.
Epinephrine Injection using Auto-Injector Syringe
Life-threatening triggers.
woman biting a big ice cube
Habits that wreck your teeth.
embarrassed woman
Do you feel guilty after eating?
pacemaker next to xray
Treatment options.
caregiver with parent
10 tips for daily life.
birth control pills
Which kind is right for you?

Women's Health Newsletter

Find out what women really need.