Skip to content
    Font Size
    A
    A
    A

    Paroxysmal Nocturnal Hemoglobinuria (PNH)

    What Is Paroxysmal Nocturnal Hemoglobinuria?

    It’s a rare blood disease that stems from your genes.  If you have it, your immune system attacks red blood cells in your body and breaks them down. They lack certain proteins that protect them.

    You can get paroxysmal nocturnal hemoglobinuria (PNH) at any age. You aren’t born with it. Although it can be life-threatening, treatments can help you feel better and control some of its complications.

    Recommended Related to

    Hemophilia A

    Important It is possible that the main title of the report Hemophilia A is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Read the Hemophilia A article > >

    The condition affects everyone differently. Some people have only minor problems. For others, it's much more severe. The biggest risk is blood clots. About 40% of people with PNH have one at some point.

    Causes

    PNH is genetic. But you don't get it from your parents, and you can't pass it on to your kids.

    A change in a gene, called a mutation, causes your body to make abnormal red blood cells. These cells don’t have proteins that shield them from your immune system. So your body breaks them down. Scientists call this process “hemolysis.”

    Some doctors believe PNH is related to weak bone marrow. People with a certain type of anemia, called aplastic anemia, are more likely to get PNH.

    The reverse is also true: People with PNH are more likely to get aplastic anemia, though not everyone does. In this condition, your bone marrow stops making new blood cells.

    Symptoms

    The condition gets its name from one of its symptoms: dark or bright red blood in your urine at night or in the morning. "Paroxysmal" means "sudden," "nocturnal" means "at night," and "hemoglobinuria" means "blood in the urine." It happens in over 60% of people with PNH.

    Symptoms of the disease are caused by:

    • Broken red blood cells
    • Too few red blood cells (which can cause anemia)
    • Blood clots in your veins

    You could have many symptoms or just a few. Usually, the more of the faulty blood cells you have in your body, the more the condition will affect you.

    Broken red blood cells and anemia may make you:

    • Feel tired and weak
    • Have headaches
    • Feel short of breath
    • Have an irregular heartbeat
    • Have belly pain
    • Have trouble swallowing
    • Have pale or yellowish skin
    • Bruise easily
    • Men may have trouble getting or keeping an erection
    1 | 2 | 3 | 4

    Hot Topics

    WebMD Video: Now Playing

    Click here to wach video: Dirty Truth About Hand Washing

    Which sex is the worst about washing up? Why is it so important? We’ve got the dirty truth on how and when to wash your hands.

    Click here to watch video: Dirty Truth About Hand Washing

    Popular Slideshows & Tools on WebMD

    disciplining a boy
    Types, symptoms, causes.
    fruit drinks
    Eat these to think better.
    Balding man in mirror
    Treatments & solutions.
    No gym workout
    Moves to help control blood sugar.
    Remember your finger
    Are you getting more forgetful?
    acupuncture needle on shoulder
    10 tips to look and feel good.
    Close up of eye
    12 reasons you're distracted.
    birth control pills
    Which kind is right for you?
    embarrassed woman
    Do you feel guilty after eating?
    woman biting a big ice cube
    Habits that wreck your teeth.
    pacemaker next to xray
    Treatment options.
    Pink badge on woman chest to support breat cancer
    Myths and facts.

    Pollen counts, treatment tips, and more.

    It's nothing to sneeze at.

    Loading ...

    Sending your email...

    This feature is temporarily unavailable. Please try again later.

    Thanks!

    Now check your email account on your mobile phone to download your new app.

    Women's Health Newsletter

    Find out what women really need.