Plicamycin (mithramycin) is an antibiotic that doctors sometimes use
Paget's disease; however, the U.S. Food and Drug
Administration (FDA) has not approved plicamycin for this purpose. It is used
for Paget's disease only if several other forms of treatment have failed.
Plicamycin slows the breakdown and rebuilding of bone tissue in the
Side effects of plicamycin include:
Plicamycin needs to be given
intravenously (IV). It is given over 4 to 6 hours for
10 days. Treatment with plicamycin may be repeated once a month.
Plicamycin can be harmful to bone marrow (where blood cells are
produced), the liver, and the kidneys. People who receive plicamycin need to
have frequent blood tests to watch for signs that the medicine might be
affecting any of these organs.
Author Shannon Erstad, MBA/MPH Editor Kathleen M. Ariss, MS Associate Editor Michele Cronen Primary Medical Reviewer Caroline S. Rhoads, MD - Internal Medicine Specialist Medical Reviewer Hanan Bassyouni, MD - Endocrinology and Metabolism
WebMD Medical Reference from Healthwise
September 30, 2005
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