Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Prerenal Acute Kidney Injury

Font Size

Topic Overview

Prerenal acute kidney injury (AKI), also called acute renal failure, occurs when a sudden reduction in blood flow to the kidney camera.gif (renal hypoperfusion) causes a loss of kidney function. In prerenal acute kidney injury, there is nothing wrong with the kidney itself.

Prerenal acute kidney injury is the most common type of acute kidney injury. It can be a complication of almost any disease, condition, or medicine that causes a decrease in the normal amount of blood and fluid in the body.

Causes of prerenal acute kidney injury include:

  • Severe blood loss and low blood pressure related to major cardiac or abdominal surgery, severe infection (sepsis), or injury.
  • Medicines that interfere with the blood supply to the kidneys. Medicines such as ACE inhibitors and common pain medicines (NSAIDs) commonly cause prerenal acute kidney injury in people who already have an increased risk for kidney problems.
  • Severe dehydration caused by excessive fluid loss.
  • Severe burns.
  • Pancreatitis and liver diseases, such as cirrhosis, that create fluid shifts in the abdomen.

Treatment focuses on correcting the cause of the prerenal acute kidney injury. Depending on the cause, the condition often reverses itself within a couple of days after normal blood flow to the kidneys has been restored. But if it is not reversed or treated successfully and quickly, prerenal acute kidney injury can cause tissue death in the kidneys and lead to intrinsic (intrarenal) acute kidney injury.


WebMD Medical Reference from Healthwise

Last Updated: November 14, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
Next Article:

Prerenal Acute Kidney Injury Topics

Hot Topics

WebMD Video: Now Playing

Click here to wach video: Dirty Truth About Hand Washing

Which sex is the worst about washing up? Why is it so important? We’ve got the dirty truth on how and when to wash your hands.

Click here to watch video: Dirty Truth About Hand Washing

Popular Slideshows & Tools on WebMD

disciplining a boy
Types, symptoms, causes.
Remember your finger
Are You Getting More Forgetful?
fruit drinks
Eat these to think better.
No gym workout
Moves to help control blood sugar.
acupuncture needle on shoulder
10 tips to look and feel good.
Close up of eye
12 reasons you're distracted.
birth control pills
Which kind is right for you?
embarrassed woman
Do you feel guilty after eating?
Epinephrine Injection using Auto-Injector Syringe
Life-threatening triggers.
woman biting a big ice cube
Habits that wreck your teeth.
pacemaker next to xray
Treatment options.
caregiver with parent
10 tips for daily life.

Women's Health Newsletter

Find out what women really need.