Prerenal acute renal failure is the most common type of acute renal
failure, accounting for about 55 out of 100 acute renal failure cases.1 It can be a complication of almost any disease, condition, or
medicine that causes a decrease in the normal amount of blood and fluid in
Goodpasture syndrome is a rare but serious autoimmune disease that attacks the lungs and kidneys.
The disease occurs when the body's immune system mistakenly produces antibodies against collagen in the lungs and kidneys. Collagen is a protein that helps form connective tissue.
Goodpasture syndrome initially causes vague symptoms such as fatigue. But it can rapidly involve the lungs and kidneys. It is almost always fatal if it is not quickly diagnosed and treated.
Severe blood loss and low blood pressure related
to major cardiac or abdominal surgery, severe infection (sepsis), or injury.
interfere with the blood supply to the kidneys. Medicines such as ACE inhibitors and common pain medicines (NSAIDs) commonly cause
prerenal acute renal failure in people who already have an increased risk for
Treatment focuses on correcting the cause of the prerenal acute renal
failure. Depending on the cause, the condition often reverses itself within a
couple of days after normal blood flow to the kidneys has been restored.
But if it is not reversed or treated successfully and quickly, prerenal
acute renal failure can cause tissue death in the kidneys and lead to intrinsic
(intrarenal) acute renal failure.
Liu KD, Chertow GM (2008). Acute renal failure. In AS
Fauci et al., eds., Harrison's Principles of Internal Medicine, 17th ed., vol. 2, pp. 1752-1761. New York:
Primary Medical Reviewer
E. Gregory Thompson, MD - Internal Medicine
Specialist Medical Reviewer
Tushar J. Vachharajani, MD, FASN, FACP - Nephrology
May 10, 2011
WebMD Medical Reference from Healthwise
May 10, 2011
This information is not intended to replace the advice of a doctor.
Healthwise disclaims any liability for the decisions you make based on this