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    Sickle Cell Disease

    Important
    It is possible that the main title of the report Sickle Cell Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • Sickle Cell Anemia
    • Sickle Cell Trait

    Disorder Subdivisions

    • Sickle Cell-Hemoglobin C Disease
    • Sickle Cell-Hemoglobin D Disease
    • Sickle Cell-Thalassemia Disease

    General Discussion

    Sickle cell disease is a rare inherited blood disorder. It is characterized by the presence of sickle or crescent shaped red blood cells (erythrocytes) in the bloodstream. These abnormally-shaped cells become rigid and lodge themselves in the very tiny blood vessels (capillaries) of the peripheral blood system (blood vessels outside of the heart). The capillaries become clogged, preventing the normal flow of oxygen to tissues. Common symptoms associated with sickle cell disease include chest pain, frequent infections, yellowing of the skin (jaundice), and low levels of circulating red blood cells (anemia). Sickle cell disease has several recognized forms including sickle cell anemia, sickle cell hemoglobin C disease and sickle cell thalassemia disease. Sickle cell disease is inherited as an autosomal recessive trait.

    Resources

    March of Dimes Birth Defects Foundation
    1275 Mamaroneck Avenue
    White Plains, NY 10605
    Tel: (914)997-4488
    Fax: (914)997-4763
    Tel: (888)663-4637
    Email: Askus@marchofdimes.com
    Internet: http://www.marchofdimes.com

    Piedmont Health Services and Sickle Cell Agency
    1102 East Market Street
    Greensboro, NC 27401
    USA
    Tel: (336)274-1507
    Tel: (800)733-8297
    Email: scdap@scdap.org
    Internet: http://www.piedmonthealthservices.org/index.html

    Cooley's Anemia Foundation, Inc.
    330 7th Ave
    Suite 900
    New York, NY 10001
    USA
    Tel: (212)279-8090
    Fax: (212)279-5999
    Tel: (800)522-7222
    Email: info@cooleysanemia.org
    Internet: http://www.cooleysanemia.org

    Sickle Cell Disease Association of America, Inc.
    231 East Baltimore Street
    Suite 800
    Baltimore, MD 21202
    USA
    Tel: (410)528-1555
    Fax: (410)528-1495
    Tel: (800)421-8453
    Email: scdaa@sicklecelldisease.org
    Internet: http://www.sicklecelldisease.org

    NIH/National Heart, Lung and Blood Institute
    P.O. Box 30105
    Bethesda, MD 20892-0105
    Tel: (301)592-8573
    Fax: (301)251-1223
    Email: nhlbiinfo@rover.nhlbi.nih.gov
    Internet: http://www.nhlbi.nih.gov/

    Sickle Cell Association of Ontario
    3199 Bathurst Street Suite 202
    Toronto
    Ontario, M6A 2B2
    Canada
    Tel: 4167892855
    Fax: 4167891903
    Email: sicklecell@look.ca
    Internet: http://www.sicklecellontario.org/

    Cochrane Cystic Fibrosis and Genetic Disorders Group
    Institute of Child Health, University of Liverpool
    Alder Hey Children's NHS Foundation Trust
    Liverpool, L12 2 AP
    United Kingdom
    Tel: 441512525696
    Email: nikkij@liverpool.ac.uk
    Internet: http://cfgd.cochrane.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Madisons Foundation
    PO Box 241956
    Los Angeles, CA 90024
    Tel: (310)264-0826
    Fax: (310)264-4766
    Email: getinfo@madisonsfoundation.org
    Internet: http://www.madisonsfoundation.org

    Sickle Cell Awareness Group of Ontario
    1280 Finch Ave W, Suite 517
    Toronto
    Ontario, M9M 2Z3
    Canada
    Tel: 4167454267
    Fax: 9058300850
    Email: info@sicklecellanemia.ca
    Internet: http://sicklecellanemia.ca/index.php

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 4/9/2008
    Copyright 1984, 1985, 1987, 1989, 1990, 1992, 1993, 1994, 1995 , 1996, 1997, 1998, 1999, 2000, 2001, 2002, 2003, 2006 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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