Splenic sequestration occurs in people who have
sickle cell disease when large numbers of sickled red
blood cells become trapped in the
spleen, causing it to suddenly enlarge. This condition is more common in infants and young children. It may follow a respiratory infection. Without
emergency medical care, splenic sequestration can cause death in a matter of
Splenic sequestration causes sudden and severe
anemia, with symptoms of sudden weakness, pale lips,
rapid breathing, excessive thirst, belly pain, and rapid heartbeat.
Blood disorders can affect any of the three main components of blood:
Red blood cells, which carry oxygen to the body's tissues
White blood cells, which fight infections
Platelets, which help blood to clot
Blood disorders can also affect the liquid portion of blood, called plasma.
Treatments and prognosis for blood diseases vary, depending on the blood condition and its severity.
Parents of babies and young children with sickle cell disease are
advised to monitor their children for spleen enlargement. The doctor can show the parent how to check for it. A suddenly enlarged spleen requires emergency medical
Primary Medical Reviewer
E. Gregory Thompson, MD - Internal Medicine
Specialist Medical Reviewer
Martin Steinberg, MD - Hematology
October 7, 2010
WebMD Medical Reference from Healthwise
October 07, 2010
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