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What may increase the risk of a problem from toe, foot, and ankle injuries?

Many conditions, lifestyle choices, medications, and diseases interfere with your ability to heal or fight infection. You may be at risk for a more serious problem from your symptoms if you have any of the following. Be sure to tell your health professional.


  • A toe, foot, or ankle condition present since birth (congenital defect)
  • Previous injury
  • Previous surgery to the injured area

Lifestyle choices

  • Alcohol abuse or withdrawal
  • Drug abuse or withdrawal
  • Smoking or other tobacco use


  • Anticoagulants, such as warfarin (Coumadin), enoxaparin (Lovenox), heparin, or aspirin
  • Chemotherapy or radiation therapy
  • Corticosteroids, such as prednisone
  • Medications to prevent organ transplant rejection


  • Autoimmune diseases, such as lupus
  • Cancer
  • Diabetes
  • Gout
  • Hemophilia
  • Human immunodeficiency virus (HIV) infection
  • Idiopathic thrombocytopenia purpura (ITP)
  • Kidney disease
  • Liver disease
  • Multiple sclerosis (MS)
  • Osteoarthritis
  • Osteomyelitis
  • Peripheral neuropathy
  • Peripheral arterial disease
  • Rheumatoid arthritis
  • Septic arthritis
  • Septic bursitis
  • Sickle cell disease
  • Venous insufficiency
Author Jan Nissl, RN, BS
Editor Susan Van Houten, RN, BSN, MBA
Associate Editor Tracy Landauer
Primary Medical Reviewer Kathleen Romito, MD - Family Medicine
Specialist Medical Reviewer Gavin W.G. Chalmers, DPM - Podiatry and Podiatric Surgery
Last Updated October 27, 2008

WebMD Medical Reference from Healthwise

Last Updated: October 27, 2008
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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