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ADHD in Children Health Center

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New ADHD Drug May Be as Good as Ritalin

Atomoxetine Could Be First Drug Approved for Adults
WebMD Health News

June 26, 2002 -- Millions of American children take Ritalin and other stimulants to control symptoms of attention deficit hyperactivity disorder (ADHD). Now, research suggests that a different type of medicine may work just as well -- even for adults.

"A major potential advantage is that this medication would not require monthly trips to a doctor's office for a new prescription, because it would not be a controlled substance like [Ritalin]," lead researcher Christopher J. Kratochvil, MD, tells WebMD.

The new study showed that the experimental drug atomoxetine works as well as Ritalin for reducing ADHD symptoms, including hyperactivity, impulsivity, and difficulty paying attention. Larger studies are needed to confirm the findings, but researchers say atomoxetine may prove to be an effective alternative to stimulants.

Ritalin and atomoxetine work differently in the brain. Ritalin affects two different chemical pathways in the brain, but atomoxetine's effects are limited to only one particular brain chemical -- norepinephrine.

In the multicenter study, sponsored by atomoxetine manufacturer Eli Lilly and Company, a WebMD sponsor, 44 school-aged children were treated with Ritalin and 184 with the experimental drug.

The two groups had similar improvements in attention and hyperactivity, as measured by parents and researchers. Overall scores on an ADHD rating scale improved by an average of 19 points for the children on atomoxetine and 18 points for those on Ritalin. Side effects were similar between the two drugs as well.

"In order to compare these two drugs head to head you would need a much larger, double-blind study [where neither the investigators or patients knew which drug they were getting]," Kratochvil says. "But we now have preliminary evidence that the therapeutic effects of atomoxetine are comparable to that of [Ritalin]." Kratochvil is an assistant professor at the University of Nebraska Medical Center.

Lilly had originally hoped for FDA approval for atomoxetine by late this year, but company spokesman David Shaffer tells WebMD that a ruling probably won't come until the spring of 2003. Shaffer says the federal agency has asked for additional data to support the company's claim that atomoxetine has no potential for abuse and should not be a controlled substance.

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