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    Long-Lasting ADHD Patch May Be an Option

    Patch Releases Ritalin-Like Drug as Long as Needed
    By
    WebMD Health News
    Reviewed by Louise Chang, MD

    Oct. 25, 2005 -- Kids who need ADHD drugs may soon have a choice: the patch or the pill.

    A new patch system delivers methylphenidate -- the main ingredient in Ritalin, Concerta, and Methylin -- throughout the day. Made by Noven and Shire pharmaceutical companies, the patch is the first ADHD drug that does not have to be taken orally. Pending FDA approval, the companies plan to call the patch Daytrana.

    Studies reported at this week's joint meeting of the American and Canadian Academies of Child and Adolescent Psychiatry find the patch works at least as well as the popular once-a-day ADHD drug. Sharon B. Wigal, PhD, director of clinical trials at the Child Development Center at the University of California, Irvine, led one of the studies.

    "The patch is different from oral stimulant medications, where the longest action is up to 10 or 12 hours. It looks like the patch goes beyond that," Wigal tells WebMD. "This is a plus, because this may really allow you to formulate a dose for individual patients. Even though we were removing the patch after nine hours, once parents administer it themselves they may determine to remove it earlier or later. That may give them more options, knowing there was continuing efficacy beyond that 12-hour time point."

    Better Behavior, Attention, Math Scores

    Wigal led a research team that gave the patch to 80 ADHD kids aged 6 to 12. Half the kids got an inert placebo patch and later switched to a real patch; the other half started with a real patch and later switched to a placebo.

    When getting the real patch, the children's ADHD was significantly better than when they got the fake patch. Their behavior and attention, tested throughout the day, improved. They also did better on age-adjusted math tests.

    The patch does have side effects.

    "It is pretty comparable to what we see with other stimulant drugs," Wigal says. "We do see effects on sleep onset and decreased appetite. And then, because this is a transdermal system, you may see a skin response. That would be something to look at if a child is more sensitive in terms of skin type."

    Children in the study are continuing to use the patch for a full year. So far, the patches aren't much of a problem.

    "We see continued maintenance in terms of the patch continuing to work and safety not being a concern," Wigal says.

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