Heart Events Rare in Kids on ADHD Drugs
No Heart Complications Seen, but Long-Term Safety Questioned
WebMD News Archive
Dec. 5, 2007 -- Stimulants used to treat attention deficit hyperactivity
disorder (ADHD) are known to raise blood pressure and heart rate,
but serious heart complications seem to be rare among the children who take
them, a new study suggests.
The findings appear reassuring, but researchers say important questions
remain about the long-term safety of widely used ADHD stimulant drugs like Adderall and Ritalin.
The researchers from the University of Florida analyzed records from 55,000
children and teens newly diagnosed with ADHD
from 1994 to 2004.
Stimulant use was found to be associated with a 20% increase in visits to
hospital ERs or doctors' offices for complaints such as heart palpitations and
racing heartbeat, compared with nonuse. But use of the drugs did not appear to
be associated with an increase in hospitalizations or deaths due to cardiac
Researcher Almut Winterstein, PhD, tells WebMD that because serious cardiac
events are so rare among children and teens, a much larger study is needed to
confirm the safety of these drugs.
"We can't really say that there is no increase in risk (for serious
cardiac events) among children who take these drugs," she says. "What
we can say is that if there is an increase in risk, it will not affect a large
number of children."
ADHD Drugs and Heart Risk
The CDC estimates that 4.4 million children between the ages of 4 and 17
have been diagnosed with ADHD, and as of 2003, 2.5 million were taking
medication for it.
Children are increasingly taking the drugs for longer and longer periods,
but little is known about their long-term cardiovascular impact, Winterstein
"The average exposure in our study was two years, but we see children
who are on these drugs for five years, 10 years, and even longer," she
She adds that it is also not clear if the drugs are safe for children with
existing heart problems or with risk factors for heart disease.
Johns Hopkins University professor of pediatrics and psychiatry Daniel
Safer, MD, agrees that much larger studies are needed to address these and
other safety issues.
"We know that stimulants like [the banned dietary supplement] ephedra
can cause life-threatening [cardiac] events," he tells WebMD. "We need
to know more about the drugs that millions of children take."