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    Fight Ragweed Allergies Without Shots

    Placing Allergen Extract Under the Tongue May Reduce Need for Antihistamines
    WebMD Health News
    Reviewed by Louise Chang, MD

    March 19, 2008 (Philadelphia) -- Shots may be fun when you're at your local bar, but for too many allergy sufferers, they're a pesky, even painful, part of ragweed season. Now, researchers report early success testing an under-the-tongue alternative to injections in people with ragweed allergies.

    In a study of 115 people with ragweed allergies, researchers found that putting ragweed extract under the tongue was safe and reduced the need for antihistamines.

    While more people have to be studied to be sure, the treatment also appeared to reduce the severity of allergy symptoms ranging from red, swollen, itchy eyes to stuffed-up and runny noses.

    The new treatment is called sublingual immunotherapy, a big term for putting tiny extracts of allergens, in this case ragweed allergens, under the tongue until tolerance develops.

    As its name implies, it's a type of immunotherapy, whose most common form is the ubiquitous allergy shot. The injections are the only treatment that's been proven to modify the natural course of the allergic disease, by reducing allergic sensitivity over time.

    They might work, "but a lot of people refuse shots for a lot of reasons," says Robert Esch, executive vice president of research and development at Greer Laboratories in Lenoir, N.C., which is developing the treatment.

    That makes new options desperately needed, he tells WebMD.

    Needs for Antihistamines Cut

    The new study, presented here at the American Academy of Allergy, Asthma & Immunology annual meeting, is the first to test sublingual immunotherapy for ragweed allergy in the U.S.

    The study involved people with hay fever brought on by a ragweed pollen allergy. They were randomly assigned to receive one of two doses of ragweed allergen extract, administered by a pump placed under the tongue, or placebo.

    "You hold it under the tongue for at least one minute, then swallow," Esch says. This is done once a day, in the morning, beginning 8 to 10 weeks before ragweed pollen season and then continuing for another eight to 10 weeks after it starts.

    The higher dose cut the need to reach for antihistamine drops, sprays, or capsules during ragweed season by more than 90%.

    There was also a 75% reduction in antihistamine use in the low-dose group as well as a 50% to 80% reduction in allergic symptoms in the low-dose and high-dose groups respectively, but these findings could have been due to chance. Esch says that's because not enough people were studied; a larger study is now enrolling patients.

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