Skip to content

    Allergies Health Center

    Font Size

    Allergy Shots to Lymph Nodes May Work Better

    'Practically Painless' Shots May Offer Quicker Relief, Researchers Report
    WebMD Health News
    Reviewed by Louise Chang, MD

    Nov. 11, 2008 -- Allergy shots given directly to the lymph nodes may bring quicker allergy relief than traditional allergy shots.

    Researchers report that news in Proceedings of the National Academy of Sciences.

    They studied 183 adults with hay fever, splitting the patients into two groups.

    One group of patients got three allergy shots to their lymph nodes over two months (one shot at the study's start, a second shot four weeks later, and the third shot eight weeks into the study).

    Patients in the other group got traditional immunotherapy, consisting of 54 under-the-skin (subcutaneous) allergy shots spread over three years.

    Patients in the lymph node group had three advantages over patients in the subcutaneous group:

    • Milder allergic reactions to the shots
    • Quicker improvement in tolerance to their allergen
    • Less use of "rescue" medicines to relieve allergy symptoms

    Three years later, the lymph node shots hadn't worn off, though patients in both groups reported similar degrees of improvement in their allergy symptoms.

    People might be more willing to get lymph node shots because fewer shots are required and they are "practically painless," write the researchers, who included Thomas Kundig, MD, of Switzerland's University Hospital Zurich.

    The journal notes that Kundig is the inventor named for intralymphatic immunotherapy (the lymph node shots) on a patent owned by the University of Zurich.

    Today on WebMD

    man blowing nose
    Make these tweaks to your diet, home, and lifestyle.
    Allergy capsule
    Breathe easier with these products.
    cat on couch
    Live in harmony with your cat or dog.
    Woman sneezing with tissue in meadow
    Which ones affect you?

    blowing nose
    woman with sore throat
    lone star tick
    Woman blowing nose

    Send yourself a link to download the app.

    Loading ...

    Please wait...

    This feature is temporarily unavailable. Please try again later.


    Now check your email account on your mobile phone to download your new app.

    cat lying on shelf
    Allergy prick test
    Man sneezing into tissue
    Woman holding feather duster up to face, twitching