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Allergies Health Center

Skin Allergies May Protect Against Cancer

Breast, Nonmelanoma Skin Cancer Rates Lower in Contact Allergy Sufferers
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WebMD Health News
Reviewed by Laura J. Martin, MD

July 12, 2011 -- There may be an upside to contact skin allergies.

New research suggests that people who develop itchy rashes when their skin comes into contact with certain metals or chemicals have a lower risk for certain cancers.

Investigators say the findings support the idea that allergies may trigger the immune system to kill cancer cells before they do damage -- a theory known as the immunosurveillance hypothesis.

Contact Allergies and Cancer

Contact allergies are delayed reactions to metals like nickel or cobalt or to chemicals, such as those found in plants such as poison ivy and poison oak, perfumes, and hair dyes.

Earlier research suggests that people who suffer from other types of allergies may have a lower risk for certain cancers, but the new study is among the first to look specifically at contact skin allergies.

The findings do not prove that contact allergies have a direct impact on cancer risk, but they do suggest an association, researcher Kaare Engkilde, PhD, of Denmark’s National Allergy Research Center, tells WebMD.

“These allergies haven’t really gotten much attention in research, but it looks like they may have a more systemic effect than we had previously thought,” he says.

Using Danish health registries, Engkilde and his research team were able to follow nearly 17,000 adults in that country who were tested for contact skin allergies between 1984 and 2008.

About one in three (35%) had positive reactions to at least one allergen. Women were more likely than men to have a contact allergy, with 41% testing positive, compared to 26% of men.

Allergic People Had Fewer Breast, Skin Cancers

Using a national cancer registry, the researchers were able to determine the study participants’ long-term risk for 15 different malignancies.

When the researchers compared the allergy and cancer data sets, they found that people with contact skin allergies had lower rates of breast and non-melanoma skin cancers.

Women with skin allergies had slightly lower rates of brain cancer, but this was not seen in men.

People with contact skin allergies had higher rates of bladder cancer, which could explain the suspected link between hair dyes and the cancer, Engkilde says.

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