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Oral Allergy Treatment May Ease Asthma, Hay Fever

This under-the-tongue alternative to shots is used in Europe, but not approved in U.S.

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Like allergy shots, immunotherapy pills and drops take time to work. They need to be taken daily, for a few years. And they're not cheap, Nelson pointed out. They can cost $2 or more a day, and insurance companies may not cover it.

As far as safety, Lin said the trials her team reviewed found no serious allergic reactions to the immunotherapy. Most often, patients had "local" reactions, such as throat irritation and swelling or itching in the mouth.

"But we didn't do an exhaustive safety review," Lin stressed. It's possible that in the real world, some patients have had more serious reactions.

Another big question is whether under-the-tongue immunotherapy is as effective as traditional allergy shots, Nelson said. "It's not clear how they compare head-to-head," he said.

On the other hand, Lin said many more U.S. patients will try immunotherapy if under-the-tongue options are approved. That's especially true of kids. "Who's going to be the least likely to accept allergy shots?" Lin said. "Young children."

Twenty of the studies her team reviewed focused solely on children. And kids seemed to fare as well as adults.

Current clinical trials in the United States are looking at under-the-tongue products for allergies to grass pollen, ragweed, cat dander and house dust mites. Lin suggested that for now, patients with allergies or allergy-induced asthma talk to their doctors about all their treatment options.

The study was funded by the U.S. Agency for Healthcare Research and Quality. Nelson has received research funds from Circassia, Ltd., which is developing so-called T-cell vaccines to treat allergies.

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