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Genetic risk: Apo E gene

(continued)

ApoE Testing in Research or Diagnosis continued...

In a research setting, APOE testing may be used to identify study volunteers who may be at a higher risk of getting AD. In this way, researchers can look for early brain changes in some patients. This test also helps researchers compare the effectiveness of treatments for patients with different APOE profiles. Most researchers believe that the APOE test is useful for studying AD risk in large groups of people but not for determining one person's individual risk. Predictive screening in otherwise healthy people will be useful if an accurate/reliable test is developed and effective ways to treat or prevent AD are available.

In diagnosing AD, APOE testing is not a common practice. The only definite way to diagnose AD is by viewing a sample of a person's brain tissue under a microscope to determine if there are plaques and tangles present. This is usually done after the person dies. However, through a complete medical evaluation (including a medical history, laboratory tests, neuropsychological tests, and brain scans), well-trained doctors can diagnose AD correctly up to 90 percent of the time. Doctors look to rule out other diseases and disorders that can cause the same symptoms of AD. If no other cause is identified, a person is said to have "probable" or "possible" AD. In some cases, APOE testing may be used in combination with these other medical tests to strengthen the diagnosis of a suspected case of AD. Currently, there is no medical test to establish if a person without the symptoms of AD is going to develop the disease. APOE testing as a patient screening (predictive) method is not recommended.

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