Mapping Of Human Genome Is a First Step To Many Answers
April 12, 2000 (Atlanta) -- The mapping of the entire genetic material in
humans will no doubt have a seismic affect on medicine in the future. But what
kind of medical breakthroughs can we expect to come out of the research, and
who will most benefit?
Researchers have been racing to be the first to map the human genome -- the
complete set of human genes -- in an effort known as the human genome project.
Knowing the function of each part of the DNA could potentially lead to the
development of drugs tailored to each individual?s genetic make-up. Doctors
would be able to pick the medication that would work best for you, and to
reduce the chance of side effects.
Already, DNA research has given doctors the ability to target the proper
doses of some drugs to people, and to rule out certain drugs for people in whom
they are likely to cause side effects. A genetic 'smart card' -- a plastic card
encoded with a person?s genetic information that patients could present to
doctors to help them make treatment choices -- is likely not far off.
"Maybe the best thing about having the human genome in hand is that it
opens up a tremendous number of possibilities to us," Elaine Mardis, PhD,
tells WebMD. But, she says, "the scenarios and how they play out are
largely speculative at this point." Mardis is the assistant director of the
genome sequencing center at Washington University in St. Louis.
"I think most reasonably well-informed people understand the sequence
won?t provide immediate answers," Mardis says. The fundamental premise of
the human genome project, and all it can really provide, Mardis says, "is
that overwhelmingly, as far as genes go, one person is reasonably close to
another person." The problem, she says, it?s the abnormal, or mutated,
genes that cause disease, and the genome project won?t answer the questions
about all those potentially lethal genes.
The new discoveries promise to be a golden opportunity for drug companies,
though, as there?s a lot of money to be made in discovering new medications.
And that, of course, is a golden opportunity for people with a variety of
The first benefits we're likely to see from the project, though, will be in
the ability to test people for certain diseases that are due to abnormal genes
they possess, such as Alzheimer?s disease, Mardis says.
She is also hopeful that researchers may be able to stop genes that are
responsible for certain deadly diseases, such as cancer. Although some
diseases, such as cystic fibrosis, are caused by a single abnormal gene, many
are due to more than one bad gene. So finding one genetic mutation may not be
the only piece to the puzzle.