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Mapping Of Human Genome Is a First Step To Many Answers

WebMD Health News

April 12, 2000 (Atlanta) -- The mapping of the entire genetic material in humans will no doubt have a seismic affect on medicine in the future. But what kind of medical breakthroughs can we expect to come out of the research, and who will most benefit?

Researchers have been racing to be the first to map the human genome -- the complete set of human genes -- in an effort known as the human genome project. Knowing the function of each part of the DNA could potentially lead to the development of drugs tailored to each individual?s genetic make-up. Doctors would be able to pick the medication that would work best for you, and to reduce the chance of side effects.

Already, DNA research has given doctors the ability to target the proper doses of some drugs to people, and to rule out certain drugs for people in whom they are likely to cause side effects. A genetic 'smart card' -- a plastic card encoded with a person?s genetic information that patients could present to doctors to help them make treatment choices -- is likely not far off.

"Maybe the best thing about having the human genome in hand is that it opens up a tremendous number of possibilities to us," Elaine Mardis, PhD, tells WebMD. But, she says, "the scenarios and how they play out are largely speculative at this point." Mardis is the assistant director of the genome sequencing center at Washington University in St. Louis.

"I think most reasonably well-informed people understand the sequence won?t provide immediate answers," Mardis says. The fundamental premise of the human genome project, and all it can really provide, Mardis says, "is that overwhelmingly, as far as genes go, one person is reasonably close to another person." The problem, she says, it?s the abnormal, or mutated, genes that cause disease, and the genome project won?t answer the questions about all those potentially lethal genes.

The new discoveries promise to be a golden opportunity for drug companies, though, as there?s a lot of money to be made in discovering new medications. And that, of course, is a golden opportunity for people with a variety of ailments.

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