Skip to content

    Alzheimer's Disease Health Center

    Font Size
    A
    A
    A

    Antipsychotic Drugs for Alzheimer's?

    Researchers Stress the Need to Weigh Drugs' Risks
    By
    WebMD Health News
    Reviewed by Louise Chang, MD

    Oct. 11, 2006 -- The antipsychotic drugs Zyprexa, Seroquel, and Risperdal may help some Alzheimer's patients, but their side effects should be carefully weighed, a new study shows.

    The 36-week study, published in The New England Journal of Medicine, included 421 people with Alzheimer's-related psychosis, aggression, or agitation.

    The patients were in their late 70s, on average.

    The University of Southern California's Lon Schneider, MD, and colleagues randomly split the patients into four groups, giving each group a different drug.

    One group received Zyprexa. Another group got Seroquel. A third group took Risperdal. For comparison, the fourth group got pills containing no medicine (placebo).

    Drug doses were adjusted as needed.

    The researchers tracked how long patients stayed on their assigned drug.

    Study's Results

    Eighty-two percent of the patients discontinued their assigned drug during the study.

    Patients in all four groups stayed on their drugs (including the placebo) for a similar average amount of time: five to eight weeks, the study shows.

    Between 16% and 24% of patients taking any of the antipsychotic drugs stopped taking those drugs due to adverse events -- such as sedation, tremors, or movement problems -- compared with 5% of those taking placebo.

    The four groups also included similar percentages of patients who showed symptom improvements (26% to 32% of those taking antipsychotic drugs and 21% of the placebo group).

    "Adverse effects offset advantages in the efficacy of atypical antipsychotic drugs for the treatment of psychosis, aggression, or agitation in patients with Alzheimer's diseaseAlzheimer's disease," the researchers write.

    By "atypical antipsychotics," they mean newer antipsychotic drugs, which include those used in this study.

    Full Results to Come

    After discontinuing their assigned drug, patients were allowed to start taking other antipsychotic drugs or citalopram, an antidepressant.

    The option to switch to another drug might have led some patients to discontinue their assigned drug, the researchers note.

    The results posted in The New England Journal of Medicine are just the first phase of a five-year study. So there are more findings to come from the study's later phases.

    "Although the differences among the groups may have been significant in a larger trial, our findings suggest that there is no large clinical benefit of treatment with atypical antipsychotic medications as compared with placebo," the researchers write.

    Today on WebMD

    Remember your finger
    When it’s more than just forgetfulness.
    senior man with serious expression
    Which kinds are treatable?
     
    senior man
    Common symptoms to look for.
    mri scan of human brain
    Can drinking red wine reverse the disease?
     
    Checklist
    ARTICLE
    eating blueberries
    ARTICLE
     
    clock
    Article
    Colored mri of brain
    ARTICLE
     
    Human brain graphic
    ARTICLE
    mature woman
    ARTICLE
     
    Woman comforting ailing mother
    ARTICLE
    Senior woman with serious expression
    ARTICLE