Skip to content
My WebMD Sign In, Sign Up

Alzheimer's Disease Health Center

Font Size

B Vitamins No Help for Alzheimer's

Alzheimer's Patients Decline Despite High-Dose Folate, Vitamin B6/B12

B Vitamins, Homocysteine, and Alzheimer's continued...

There's no doubt that B vitamins lower homocysteine. In the Aisen study, Alzheimer's patients who took folate (5 milligrams/day), vitamin B6 (25 milligrams/day), and vitamin B12 (1 milligrams/day) had 31% lower homocysteine levels than patients taking placebo.

But that didn't seem to help -- at least among patients with no underlying vitamin deficiency.

"We were successful in lowering homocysteine, but it had absolutely no effect on the clinical symptoms of Alzheimer's disease," Aisen says.

Shao notes that patients in the Aisen study did not have particularly high homocysteine levels to begin with. He says the study has not answered the question of whether Alzheimer's patients with extremely high homocysteine levels might benefit from high-dose B vitamins.

It's time to move on, says Aisen, who serves as director of the Alzheimer's Disease Cooperative Study (ADCS) that investigates potential new Alzheimer's treatments.

"I think this study is the end of the treatment of Alzheimer's disease with these vitamins," he says.

The Aisen study, and an editorial by Clarke and colleague Derrick A. Bennett, PhD, appear in the Oct. 15 issue of TheJournal of the American Medical Association.

1|2

Today on WebMD

alzheimer's disease warning signs
ARTICLE
Alzheimers Overview
SLIDESHOW
 
Best Memory Boosting Games
ARTICLE
mri scan of human brain
QUIZ
 
senior man
ARTICLE
daughter and father
ARTICLE
 
Making Diagnosis
Article
Colored mri of brain
ARTICLE
 
Close up of elderly couple holding hands
VIDEO
senior woman with lost expression
ARTICLE
 
Woman comforting ailing mother
ARTICLE
Alzheimers Dementia
ARTICLE