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Pick Disease

It is possible that the main title of the report Pick Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


  • diffuse degenerative cerebral disease
  • lobar atrophy of the brain
  • dementia with lobar atrophy and neuronal cytoplasmic inclusions
  • Pick disease of the brain
  • frontotemporal lobar degeneration

Disorder Subdivisions

  • frontotemporal dementia with parkinsonism-17
  • frontotemporal dementia associated with motor neuron disease
  • primary progressive aphasia (nonfluent type)
  • behavioral variant frontotemporal dementia
  • semantic dementia

General Discussion

Pick disease is a form of dementia characterized by behavioral changes such as deterioration of social skills and changes in personality. Intellectual impairment, memory loss and language deterioration may also occur. Most cases of Pick disease are sporadic in nature, but a genetic form of the disease is recognized. Although a progressive form of communication impairment (aphasia) may occur as part of Pick disease, people with Pick disease have other behavioral problems besides language and communication impairment.


WE MOVE (Worldwide Education and Awareness for Movement Disorders)
5731 Mosholu Avenue
Bronx, NY 10471
Tel: (347)843-6132
Fax: (718)601-5112

Parkinson's Disease Foundation, Inc.
1359 Broadway
Suite 1509
New York, NY 10018
Tel: (212)923-4700
Fax: (212)923-4778
Tel: (800)457-6676

Alzheimer's Association
225 N. Michigan Avenue
17th Floor
Chicago, IL 60601
Tel: (312)335-8700
Fax: (866)699-1246
Tel: (800)272-3900
TDD: (312)335-5886

Alzheimer's Disease Education and Referral Center
P.O. Box 8250
Silver Spring, MD 20907-8250
Tel: (301)495-3311
Fax: (301)495-3334
Tel: (800)438-4380

NIH/National Institute on Aging
31 Center Drive, MSC 2292
Building 31
Room 5C27
Bethesda, MD 20892
Tel: (301)496-1752
Fax: (301)496-1072
Tel: (800)222-2225
TDD: (800)222-4225

NIH/National Institute of Neurological Disorders and Stroke
P.O. Box 5801
Bethesda, MD 20824
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
TDD: (301)468-5981

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223

C-Mac Informational Services, Inc.
120 Clinton Lane
Cookeville, TN 38501-8946
Tel: (931)268-1201

Association for Frontotemporal Degeneration
Radnor Station Building #2, Suite 320
290 King of Prussia Road
Radnor, PA 19087
Tel: (267)514-7221
Tel: (866)507-7222

For a Complete Report:

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site or email

Last Updated: 4/9/2012
Copyright 1989, 1990, 1996, 1997, 1998, 2000, 2009, 2012 National Organization for Rare Disorders, Inc.

WebMD Medical Reference from the National Organization for Rare Disorders

Last Updated: 8/, 015
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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