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    Kava for Anxiety: Is Short-Term Use Safe?

    Study Shows Supplement Was Safe and Effective in People Using Supplement for 1 Week
    WebMD Health News
    Reviewed by Louise Chang, MD

    May 14, 2009 -- A water-soluble extract of the plant kava was found to be safe and highly effective for the short-term treatment of anxiety in a new study. But concerns about its long-term safety and the safety of other kava formulations remain.

    A decade ago, kava supplements were a popular alternative treatment for anxiety and related conditions, with U.S. sales approaching $50 million in 1998 alone.

    But reports of liver damage and even liver failure linked to its use led to bans of kava supplements in many countries, including Canada, Germany, France, and the U.K.

    Kava was not banned in the U.S., but sales fell dramatically after the FDA issued a warning about possible liver-related injury in March 2002.

    Kava Under Scrutiny

    In 2007, a safety panel of the World Health Organization (WHO) reported a possible link between kava use and seven deaths and 14 liver transplants, mostly in Europe.

    But the WHO report suggested that liver toxicity may be limited to kava formulations that used the whole kava plant, instead of just the root, or used acetone and ethanol to extract the active ingredient from the plant instead of water.

    "Kava has been used in the Pacific Islands where it is grown for centuries without evidence of liver problems," researcher Jerome Sarris, of Australia's University of Queensland tells WebMD. "But they only use water-soluble extract and they only use the peeled root of the plant."

    Sarris says he used a product that mirrored the traditional kava used by the Pacific Islanders as closely as possible in his study, published in Psychopharmacology.

    Thirty-seven people with generalized anxiety and varying levels of the depression completed the three-week long trial. In the first week, all participants took a placebo. In the second week, half the participants took kava tablets and the other half took placebo tablets. In the third week, the group that had taken kava tablets was switched to a placebo and the group that had taken a placebo switched to kava tablets. Participants were not aware whether they were taking a placebo or kava tablets.

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