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Arthritis Health Center

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Group Calls for 2 Arthritis Drug Bans

Public Citizen Says Celebrex, Bextra Share Vioxx's Problems
WebMD Health News

Jan. 24, 2005 -- A pharmaceutical watchdog group called on federal regulators Monday to ban two prescription pain relief medications similar to Vioxx, saying the drugs increase the risk of heart attacks and other cardiovascular problems.

Public Citizen filed a petition with the FDA asking the agency to immediately remove Celebrex and Bextra from the market. Celebrex and Bextra are two arthritis drugs in a class known as Cox-2 inhibitors. According to the group, Americans filled more than 36 million prescriptions of these drugs last year.

Public Citizen is a longtime critic of both the pharmaceutical industry and the FDA, and it independently warned patients more than four years ago that Celebrex was unsafe.

The group said Monday that studies show that Celebrex and Bextra increase the likelihood of dangerous heart problems while offering patients little or no benefit over older pain relievers.

"Both drugs are fundamentally dangerous, and the only way of dealing with that is to get them off the market," Sidney Wolfe, MD, head of Public Citizen's Health Research Group, tells WebMD.

Wolfe says the group does not have data suggesting how many adverse health events may have resulted from the use of the two drugs.

Similar Drug Pulled From Market

The petition comes after Merck & Co. voluntarily pulled Vioxx from the market in September 2004 following reports of increased heart attack risk in patients taking it. The move prompted some experts to speculate that the side effects are not unique to Vioxx but could be shared by the entire class of Cox-2 inhibitor drugs.

FDA scientist David Graham, MD, singled out Bextra and four other prescription drugs as potentially unsafe in November 2004 when he testified in front of the Senate Finance Committee about drug safety problems at the FDA.

Cox-2 inhibitors are widely used in patients with joint pain because they generally avoid the risk of stomach bleeding caused by nonsteroidal anti-inflammatory drugs like ibuprofen.

In one study published in 2000, researchers found that patients taking Celebrex had a slightly higher chance of developing chest pain (angina) than those taking ibuprofen. The study findings did not reach mathematical significance, meaning the results could have been by chance. However, FDA scientists at the time cited a "consistent and worrisome trend" in several studies pointing to cardiovascular toxicity caused by the drug.

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