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Arthritis Health Center

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Study: No Long-Lasting Vioxx Heart Risk

Risk Goes Away When Vioxx Use Stops; Low-Dose Celebrex Seems Safe
WebMD Health News

Jan. 31, 2005 -- The heart attack risk linked to Vioxx goes away after a person stops taking the drug, data from elderly Canadians shows.

"It wasn't enough you took Vioxx three months ago -- you actually had to be currently exposed to have an increased risk of heart attack," James M. Brophy, MD, PhD, tells WebMD. "How long after you take Vioxx would you be considered at risk? More studies are needed to tease that out."

Brophy and colleagues at McGill University in Montreal reviewed medical records on nearly 114,000 people over the age of 66. They used the data to look at who did and who did not have a heart attack after beginning NSAID treatment.

NSAIDs (nonsteroidal anti-inflammatory drug) include traditional anti-inflammatory drugs, such as ibuprofen and naproxen, as well as newer ones, such as Celebrex and Vioxx. The new drugs -- known as Cox-2 inhibitors -- got their name because they selectively block an enzyme called Cox-2.

Brophy's team has more good news. Celebrex -- at low doses -- does not appear to increase heart attack risk.

"Yes, our study suggests that low-dose Celebrex is safe," Brophy says. "This is not a randomized study, so it is not proof of safety. But within the limits of an observational study, our data provides an element of confidence that Celebrex -- at least in conventional low dose of 200 milligrams per day -- appears to be very safe."

On the other hand, the study confirms that Vioxx -- even at a low dose -- actually does increase a person's risk of heart attack.

"Our data would tend to support the wisdom of taking Vioxx off the market," Brophy says. "The data already was rather conclusive from clinical trials. We add an element of precision, in that we have looked at a much larger population. ... In our study, 239 patients were taking Vioxx at the time of their heart attack. So we add a sense of confirmation and precision to this."

The findings come from elderly people who'd never had a heart attack before taking an NSAID.

How Safe Is High-Dose Celebrex?

Merck pulled Vioxx off pharmacy shelves when it became clear that the drug raised the risk of heart attacks. Fearing that other Cox-2 drugs might have similar -- if less dramatic -- side effects, doctors have been much more careful in prescribing Celebrex and Bextra. Some groups have called for a ban on these drugs until their heart safety can be assured.

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