New Drug May Help Fight Severe Gout
Study Shows Rilonacept Decreases Pain in Gout Patients
Nov. 9, 2007 (Boston) -- A new inflammation-fighting drug may spell relief for people with severe gout who are unable to take other drugs for gout treatment because of underlying health problems.
Given by injection just underneath the skin, rilonacept (IL-1 Trap) blocks interleukin-1, a protein involved in inflammation. A new study of 10 people with severe gout shows that it substantially decreases both disease activity and pain.
The findings were presented at the American College of Rheumatology's Annual Scientific Meeting in Boston.
"Lots of gout patients can't take standard anti-inflammatory drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, or systemic steroids because they may have kidney problems, heart problems, or diabetes," explains researcher Robert Terkeltaub, MD.
Terkeltaub is section chief of rheumatology-allergy at the VA Medical Center in San Diego and a professor of medicine at the University of California, San Diego. "Now we can help break the inflammatory loop in these patients," he says.
"IL-1 is a lynch pin of gout inflammation, and if we can block the lynch pin, we can stop the inflammatory cascade," Terkeltaub tells WebMD.
Gout is a condition characterized by "flares" of intense pain, redness, inflammation, and warmth in the affected joint. It is caused by an accumulation of uric acid crystals in joints, which can also build up in other areas of the body. As the disease progresses, these flares may become more frequent and patients may develop joint deformity and large deposits of crystals, which can become visible under the skin (called tophi). Patients with gout can also develop kidney stones and kidney damage.
Uric acid is found naturally in the body. In gout, there is generally a problem with either too much production of uric acid or problems in getting rid of the uric acid, or both. During an attack, gout is typically treated with drugs that cool inflammation. In addition, uric-acid-lowering drugs are sometimes prescribed.
Some uric-acid-lowering drugs actually cause flares, and it is possible the new drug may be used along with drugs to lower uric acid to help prevent such flares.