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Glucosamine: No Help for Hip Arthritis?

Dutch Study Shows Popular Supplement No Better Than Placebo; Industry Disagrees

Another View: Jury Is Out

In an editorial accompanying the study, authors from another Dutch medical center note that "the study is indeed negative" but caution that the results apply only to hip osteoarthritis. They conclude that the role of glucosamine in arthritis treatment is still under debate.

They also note that when the authors looked at a subset of people with osteoarthritis in other parts of their bodies, they found a small trend toward pain reduction and improved functioning, but the change wasn't significant.

A better group of patients to study would have been those with more severe arthritis because the disease progresses more rapidly then, and it might have been easier to see any effect of the supplement, wrote Johannes W.J. Bijlsma, MD, PhD, and Floris P.J.G. Lafeber, PhD, of the University Medical Center Utrecht.

Industry Responds

"What they did was study people too early in the arthritic process," agrees Luke Bucci, PhD, vice president of research at Schiff Nutrition International in Salt Lake City, which makes a glucosamine supplement.

He says that "they were starting to see some small advantages for the glucosamine group."

A Clinician's View

The study findings don't surprise Jay Mabrey, MD, chief of orthopedics at Baylor University Medical Center in Dallas. Nor does he expect this study to be the last word on the supplement.

"There are people who really believe in this and I am sure they will proceed with their own studies," Mabrey says.

His advice about its use? "I don't discourage it, and that's different from encouraging [its use]," he says. "It seems about half my patients [who use the supplement] report some type of relief, but that could very well be placebo effect." When patients ask, he tells them: "So far the studies don't show any definite advantage." But "as far as we know," it doesn't appear to do harm, he says.

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