Psoriatic arthritis generally keeps a low profile. Before pro-golfer Phil Mickelson went public about having psoriatic arthritis, many people may not have known about it.
WebMD researched the most common psoriatic arthritis treatment options and the latest developments in psoriatic arthritis joint and skin care, plus treatments that have emerged in recent years, and how psoriatic arthritis management can improve the quality of your life and prevent long-term damage.
Psoriatic Arthritis Medications
Nearly 7.5 million people in the U.S. have psoriasis. Between 10% and 30% of people with psoriasis develop psoriatic arthritis. Both conditions lead the immune system to attack healthy cells in your skin or joints. Left untreated, psoriatic arthritis can cause intense pain and leave joints permanently deformed.
Treatment for psoriatic arthritis depends on your symptoms. The most commonly used medications include:
- Nonsteroidal anti-inflammatory drugs: NSAIDs can reduce pain, swelling, and inflammation, which can help loosen up joints that may be especially stiff in the mornings. They are available by prescription or over-the-counter in the form of aspirin, ibuprofen, or naproxen sodium.
Disease-modifying antirheumatic drugs: DMARDs treat psoriasis by blocking certain activities in the immune system and slowing the growth of skin cells. DMARDs include:
Tumor necrosis factor blockers: TNF blockers are a special type of DMARD called biologic DMARDs. They can relieve psoriatic arthritis symptoms and prevent long-term damage by blocking certain activities in the immune system. TNF blockers need to be injected or given in an IV, depending on which kind is being used. TNF blockers include:
- Etanercept (Enbrel)
- Infliximab (Remicade)
- Adalimumab (Humira)
- Certolizumab pegol (Cimzia)
- Phosphodieasterase-4 (PDE-4) inhibitor: The only drug currently in this category is Otezla. It's FDA-approved for psoriatic arthritis treatment and taken orally. Side effects include diarrhea, nausea, weight loss, and depression.
New Developments in Psoriatic Arthritis Medications
New treatments have improved the outlook for people with psoriatic arthritis. "The goal of treatment should be a dramatic improvement in pain so it doesn't impact the patient's tasks of daily living," says Alice Gottlieb, MD, PhD, chair of dermatology at Tufts Medical Center.
"Since the early 2000s, when TNF blockers were first used for psoriatic arthritis, the bar for treatment has been raised," says Christopher Ritchlin, MD, a rheumatologist at the University of Rochester Medical Center. For many people, TNF blockers restore their energy, their ability to function, and their overall quality of life, especially at first.
"The response sometimes diminishes over time," says Ritchlin. If and when this happens, doctors have a number of options to restore relief, either by adding another medication to the treatment plan or by trying a different TNF-blocker.