Juvenile Idiopathic Arthritis Symptoms - Topic Overview
The most common symptoms of all forms of
juvenile idiopathic arthritis (JIA) include: Joint pain and swelling that may come and go but
are most often persistent. Symptoms must last for 6 weeks before a diagnosis of
JIA can be made. Joint stiffness that lasts longer than 1 hour in
the morning. Irritability, refusal to walk, or protection or
guarding of a joint. You might notice your child limping or avoiding the use of
a certain joint. Often unpredictable changes in symptoms, from periods with no
symptoms (remission) to flare-ups.
Additional symptoms vary depending on which type of JIA a
Symptoms of different types of JIA Effects of disease Joints affected Eye disease (chronic uveitis) Other features Oligoarticular JIA (persistent or extended) 1 to 4 joints affected in the first 6 months Knees and ankles most commonly affected Asymmetric joint
symptoms (for example, one knee) In persistent oligoarthritis, 4 or fewer joints are affected after the first 6 months. In extended oligoarthritis, 5 or more joints are affected after the first 6 months. Up to 30 out of 100 children Risk is higher in children who have antinuclear antibody (ANA) in their blood Rarely have whole-body symptoms Uneven leg bone growth possible, resulting in muscle wasting and legs of different lengths 3 Polyarticular JIA, RF-negative 5 or more joints affected in the first 6 months Large and small joints Neck and jaw often affected Symmetric joint symptoms (for example, both
knees) or asymmetric About 10 out of 100 children Risk is higher in children who have antinuclear antibody (ANA) in their blood Polyarticular JIA, RF-positive 5 or more joints affected in the first 6 months Often affects small joints such as those in the hands Symmetric and aggressive joint symptoms At least 2 positive tests for rheumatoid factor, at least 3 months apart Rheumatoid nodules in about 10 out of 100 children Bone growth problems High risk of problems as an adult Systemic JIA Joint swelling and pain not necessarily present at
onset; eventually affects a few or many joints Whole-body symptoms, including once- or twice-daily fever spikes;
generalized body pain; rash; mild appetite loss; fatigue; weakness; and enlarged lymph nodes, liver, and spleen Sometimes heart complications 2 Enthesitis-related JIA Both arthritis and enthesitis (tenderness where tendons and ligaments attach to bones) Mostly legs and feet Spine may be affected over time Yes, but the frequency is unclear May develop irritable bowel May develop sacroiliac tenderness (where the spine meets the pelvis) 1 May develop low back and buttock pain and inflammation 1 May have antigen called HLA-B27 in the blood 1 May have family history of a condition related to HLA-B27, such as ankylosing spondylitis 1 Psoriatic JIA Small and medium joints Asymmetric joint symptoms About 15 out of 100 children Psoriasis in about 50 out of 100 children May have problems with fingernails or toenails, including pitting of the nails or separation of the nail from the nail bed (onycholysis) May have family history of psoriasis in a close relative
This information is produced and provided by the National
Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National
Institute via the Internet web site at http://
.gov or call 1-800-4-CANCER.
WebMD Medical Reference from Healthwise
June 05, 2012
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