Skip to content
My WebMD Sign In, Sign Up

Arthritis Health Center

Font Size

Understanding Arthritis and Inflammation

The body's white blood cells and chemicals protect our bodies from infection by foreign substances, such as bacteria and viruses.

In some inflammatory diseases, however, the body's defense system -- the immune system -- triggers a response when there are no foreign substances to fight off. In these diseases, called autoimmune disorders, the body's normally protective immune system causes damage to its own tissues. The body responds as if normal tissues are infected or somehow abnormal.

What Diseases Are Associated With Inflammation?

Some, but not all, types of arthritis are the result of misdirected inflammation. Arthritis is a general term that describes inflammation in the joints. Some types of arthritis associated with inflammation include the following:

  • Rheumatoid arthritis
  • Psoriatic arthritis
  • Gouty arthritis

Other painful conditions of the joints and musculoskeletal system that may not be associated with inflammation include osteoarthritis, fibromyalgia, muscular low back pain, and muscular neck pain.

What Are the Symptoms of Inflammation?

Inflammation is characterized by:

  • Redness
  • Swollen joint that's warm to the touch
  • Joint pain
  • Joint stiffness
  • Loss of joint function

Often, only a few of these symptoms are present.

Inflammation may also be associated with general "flu-like" symptoms including:

  • Fever
  • Chills
  • Fatigue/loss of energy
  • Headaches
  • Loss of appetite
  • Muscle stiffness

What Causes Inflammation and What Are Its Effects?

Inflammation occurs when chemicals from the body's white blood cells are released into the blood or affected tissues to protect your body from foreign substances. This release of chemicals increases the blood flow to the area of injury or infection, and may result in redness and warmth. Some of the chemicals cause a leak of fluid into the tissues, resulting in swelling. This protective process may stimulate nerves and cause pain.

The increased number of cells and inflammatory substances within the joint cause irritation, swelling of the joint lining, and eventual wearing down of cartilage (cushions at the end of bones).

How Are Inflammatory Diseases Diagnosed?

Inflammatory diseases are diagnosed after careful evaluation of the following:

  • Complete medical history and physical exam
  • The location of painful joints
  • Presence of joint stiffness in the morning
  • Evaluation of other symptoms
  • Results of X-rays and other tests

Can Inflammation Affect Internal Organs?

Yes. Inflammation can affect organs as part of an autoimmune disorder. The type of symptoms experienced depends on which organs are affected. For example:

  • Inflammation of the heart (myocarditis) may cause shortness of breath or fluid retention.
  • Inflammation of the small tubes that transport air to the lungs may cause an asthma attack.
  • Inflammation of the kidneys (nephritis) may cause high blood pressure or kidney failure.

Pain may not be a primary symptom of an inflammatory disease, because many organs do not have pain-sensitive nerves. Treatment of organ inflammation is directed at the cause of inflammation whenever possible.

WebMD Medical Reference

Today on WebMD

Osteoarthritis Overview Slideshow
Slideshow
Sore feet with high heel shoes
SLIDESHOW
 
Knee exercises
Slideshow
Woman in gym
Slideshow
 
xray of knees with osteoarthritis
Slideshow
close up of man wearing dress shoes
Slideshow
 
feet with gout
Quiz
close up of red shoe in shoebox
Slideshow
 
salad
Video
two male hands
ARTICLE
 
Woman massaging her neck
Quiz
5 Lupus Risk Factors
Article