Easing Kids' Breathing Before Asthma
Study: Inhaled Steroids Cut Asthma-Like Symptoms During Treatment
WebMD News Archive
During the two-year treatment period, all of the kids grew taller. But there
was a slight difference in height gain between the two groups.
The average height increase after 24 months of treatment was about
four-tenths of an inch (1.1 centimeters) less for kids in the Flovent group,
compared with the placebo group.
By the end of the observation year, the groups' difference in average height
increase had narrowed to less than three-tenths of an inch (0.7
"It remains to be determined whether height will become similar in the
two groups as the cohort matures, in a manner similar to that observed in older
children," Guilbert's team writes.
In the journal, Guilbert and several of the other researchers report ties to
various drug companies, including GlaxoSmithKline, which supplied the study's
Flovent and placebo. GlaxoSmithKline is also a WebMD sponsor. The study was
funded by grants from the National Heart, Lung, and Blood Institute, a branch
of the National Institutes of Health.
The journal also contains an editorial by Diane Gold, MD, MPH, and Anne
Fuhlbrigge, MD. They work at Harvard Medical School and Boston's Brigham and
Gold and Fuhlbrigge write that "the study by Guilbert et al. strengthens
the evidence that treatment with inhaled corticosteroids in early life does not
alter the natural history of asthma."
However, the editorialists also note that Guilbert's study "offers
strong evidence supporting the use of twice-daily inhaled corticosteroids"
to control asthma-like symptoms in certain high-risk children.