Pesticides May Up Asthma in Farm Women

Allergy Protection From Growing Up on Farm Cut in Pesticide Users

From the WebMD Archives

Dec. 28, 2007 -- Farm women who use pesticides are more likely than nonusers to develop allergic asthma as adults, a U.S. study shows.

This effect is particularly strong for the 60% of farm women who grew up on a farm. People who grow up on farms have a reduced risk of allergies. Pesticide users have less of this protection, find Jane A. Hoppin, ScD, of the National Institute of Environmental Health Sciences, and colleagues.

"Growing up on a farm is such a huge protective effect it's pretty hard to overwhelm it," Hoppin said in a news release. "There is a difference in asthma prevalence between women who did and did not use pesticides, but whether it is causal or not remains to be seen."

Hoppin's team collected self-reported data from 25,814 farm women from Iowa and North Carolina. This data included detailed information on pesticide use and whether, as adults, they had doctor-diagnosed allergic or nonallergic asthma.

Farm women who grew up on farms were about half as likely to have allergic asthma (and about 20% less likely to have nonallergic asthma) as were women who were not farm children. Yet pesticide use was most strongly linked to allergic asthma in farm-raised women.

"It is likely that the association with pesticides is masked in the general population due to a higher baseline rate of asthma," Hoppin suggests.

Use of any pesticide on the farm upped a woman's risk of allergic asthma by 46%, but did not increase risk of nonallergic asthma. Even so, the risk was not huge. Only 181 of 14,767 pesticide users reported allergic asthma.

Ten of 31 analyzed pesticides were linked to allergic asthma, including two herbicides (2,4-D and glyphosate), seven insecticides (carbaryl, coumaphos, DDT, malathion, parathion, permethrin on animals, and phorate), and one fungicide (metalaxyl).

"Pesticides, particularly organophosphate insecticides, may increase asthma risk," Hoppin and colleagues conclude.

However, just because there is a link between pesticides and allergic asthma doesn't necessarily mean pesticides cause asthma. Hoppin says that in 2008, her team is hoping to start a new study to better evaluate this link.

Their current report appears in the Jan. 1 issue of the American Journal of Respiratory and Critical Care.

WebMD Health News Reviewed by Louise Chang, MD on December 28, 2007

Sources

SOURCES: Hoppin, J., American Journal of Respiratory and Critical Car, Jan. 1, 2008; vol 177: pp 11-18. News release, American Thoracic Society.

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