Oral Drops Cut Kids’ Asthma Symptoms
Under-the-Tongue Asthma Therapy Reduces Disease Severity, Research Shows
WebMD News Archive
March 4, 2008 -- An oral alternative to allergy shots shows promise for the
treatment of children with allergic asthma, a review of the
Sublingual immunotherapy (SLIT) involves taking extracts of allergens under
the tongue, which triggers asthma and allergies and increases the
tolerance to these triggers. It works in the same way that allergy shots reduce
allergic sensitivity in many patients over time.
This type of treatment, known as immunotherapy, has been shown effective for
allergic respiratory disease when given in injection form in studies. But the
value of SLIT therapy for the treatment of asthma,
especially in children, has been less clear.
Although a popular treatment for allergies and asthma in many
European countries, sublingual therapy has not been approved for use in the
SLIT Reduces Asthma Symptoms
In the newly published analysis, researchers from Italy's University of
Genoa combined the results of nine studies involving 441 children and teens with allergic asthma
treated with either sublingual immunotherapy or placebo.
They report that treatment with SLIT was associated with a reduction in
symptoms and use of rescue medication for asthma, compared to treatment with
More side effects were seen in the SLIT-treated patients, but none involved
anaphylaxis, which is a rare,
potentially life-threatening complication of injection immunotherapy. The most
common side effects noted in the SLIT-treated patients included oral symptoms,
nose and eye symptoms, and gastrointestinal symptoms.
Researcher Martin Penagos, MD, and colleagues conclude that SLIT appears to
be an effective and safe treatment in children, with the potential to reduce
the severity of asthma symptoms over time.
"Due to the favorable safety profile and its potential in modifying the
evolution of disease, SLIT is of relevant value in the treatment of asthma in
association with standard drug therapy," they write in the March issue of
the journal Chest.
Unanswered Questions About SLIT
Because SLIT does not require weekly or even twice-weekly visits to an
allergist the way allergy shots do, it has the potential to greatly expand the
pool of patients on immunotherapy for allergies and asthma, allergy and asthma specialist Linda S.
Cox, MD, tells WebMD.