Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Asthma Health Center

Font Size

Oral Contraceptives May Help Treat Asthma

Study Shows Oral Contraceptives May Benefit Some Premenstrual Women
WebMD Health News

Nov. 6, 2009 -- Treatment with oral contraceptives may benefit premenopausal women with asthma, even if their asthma symptoms are not strongly linked to their monthly menstrual cycles, early research suggests.

In a small but rigorously designed study, researchers from the University of Alberta confirmed that fluctuating levels of the sex hormones estrogen and progesterone have a direct impact on markers of airway inflammation.

Oral contraceptives are already used as a complementary asthma treatment in women whose symptoms are closely tied to their menstrual cycles.

The new research suggests a much broader group of women may also benefit, study researcher Piush J. Mandhane, MD, PhD, tells WebMD.

"Until now, we did not have the data to show that estrogen and progesterone influence asthma," he says. "Now we have it and it opens up new areas of inquiry for the management of asthma in women."

Hormones, Asthma Symptoms Measured Daily

The study included 17 premenopausal women with moderate to severe asthma who met with the research team daily over the course of a complete menstrual cycle (around 36 days).

Estrogen and progesterone levels were measured at each visit. Asthma symptoms and markers of airway inflammation were also monitored daily, and allergy skin-prick tests were conducted every other day.

"This study took a lot of dedication on the part of everyone involved," Mandhane says. "We endured snow storms, power outages, and university closures. When people were going away for weekend trips I would be at their house at 5 a.m. or an assistant would be there."

This dedication meant that almost 99% of the planned daily assessments were actually carried out.

Nine of the women in the study were using oral contraceptives and eight were not. Four of the 17 had menstrual-cycle associated asthma symptoms.

"Since women taking oral contraceptives don't have significant changes in estrogen and progestin through their menstrual cycles, we did not expect to see changes in markers of asthma through the cycle," Mandhane says. "Women who are not on oral contraceptives should have changes in estrogen and progesterone and as a result they should have changes in these markers. That is what we found."

He says women who experience big fluctuations in progesterone but few changes in estrogen during their cycle are probably most vulnerable to cycle-related asthma.

The study was published this week in the November issue of the journal Chest.

Mandhane believes the findings justify larger studies examining oral contraceptives as a treatment for asthma in premenopausal women.

When Is Your Asthma Worse?

When Is Your Asthma Worse?

Take the WebMD Asthma assessment to get Personalized Action Plan

Start Now

Today on WebMD

Lung and bronchial tube graphic
5 common triggers.
group jogging in park
Should you avoid fitness activities?
asthma inhaler
Learn about your options.
man feeling faint
What’s the difference?
Madison Wisconsin Capitol
woman wearing cpap mask
red wine pouring into glass
Woman holding inhaler
Man outdoors coughing
Lung and bronchial tube graphic
10 Worst Asthma Cities