Terbutaline for Slowing Preterm Labor
Terbutaline is sometimes used as
a tocolytic medicine to slow uterine contractions
Terbutaline should not be used for longer than 72 hours for the treatment of preterm labor.
How It Works
Terbutaline can relax
smooth muscles, like the uterus. It also affects the smooth muscles
of the blood vessels and the small airways of the lungs.
Why It Is Used
Terbutaline can be used
during preterm labor when:
- Labor needs to be delayed for 24 to 48 hours
corticosteroids, given to the mother, help fetal lungs
- Provide time to move a mother to a hospital that provides
neonatal intensive care, if her local hospital does not.
- Regular uterine contractions have thinned
cervix less than 80% and opened (dilated) it less than
4 cm, and the mother's amniotic sac has not broken.
- The mother is
- The fetus is alive and not in distress.
Depending on the medical facility, terbutaline
may be the first medicine used to delay premature birth.
How Well It Works
Terbutaline can be effective when labor needs to be delayed for 24 to 48 hours.
But the medicine usually does not completely stop contractions. Nor has it been shown
to lower risks for the premature baby.1, 2
Side effects are common with terbutaline use and may affect both the mother and fetus.
Common side effects of this medicine include:
See Drug Reference for a full list of side effects. (Drug
Reference is not available in all systems.)
What To Think About
treatment is effective, its effect typically lasts no more than 48 hours.
Long-term treatment is not advised (based on the risk of serious side effects) and is not effective.1
- The risks of treatment with terbutaline must be weighed against the
benefit of delaying birth.
- Terbutaline can greatly increase the
mother's and fetus's pulse. The mother must have her blood pressure and pulse
checked frequently during the first few hours of treatment.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
Cunningham FG, et al., eds. (2010). Preterm birth. In
Williams Obstetrics, 23rd ed., pp. 804–831. New York:
Haas DM (2011). Preterm birth, search date June 2010.
BMJ Clinical Evidence. Available online:
Other Works Consulted
Primary Medical Reviewer
||Sarah Marshall, MD - Family Medicine
Specialist Medical Reviewer
||William Gilbert, MD - Maternal and Fetal Medicine
||January 8, 2013