Popular Painkillers May Increase Risk of Miscarriage
For women with conditions such as rheumatoid arthritis or lupus, who depend on NSAIDs to live a normal life, Toledo says, "they may have no choice but to take [an NSAID]. If she were my patient, I might [recommend trying to] tough it out with some other drug during the first trimester, when miscarriage is most likely to occur. ... It may be, though, that the benefits of NSAIDs outweigh the potential risks."
Still, Toledo believes in erring on the side of caution. He tells WebMD, "We need to be cautioning our patients ... about any medicines taken while a woman is attempting pregnancy or as soon as she finds out she is pregnant. "... This [study] is going to raise my level of concern so that I'm going to tell my patients who are trying to get pregnant not to take [an NSAID during pregnancy or] ... during that two weeks between ovulation and the first missed period."